Hormonal

Sermorelin

GHRH fragment

Studied forGrowth-hormone response14
Community reportsSleep · recovery5

Historical Geref approval; discontinued. FDA determined its withdrawal was not for safety or effectiveness reasons.

What does it do?

A GHRH analogue historically approved as Geref for pediatric GH deficiency; contemporary anti-aging use has a different evidence base.

Approved & studied uses

GH secretion research

1

Small studies examined hormone and functional responses in older men.

Historical diagnostic use

4

Geref evaluated pituitary GH reserve under specialist supervision.

Community uses Reported, unvalidated

Hormonal

18

GH release, feedback-preserving stimulation and IGF-1 research.

Body composition

18

Lean mass, recovery, skin and age-related GH-decline claims.

Nasal

18

Delivery/preference research; variable absorption.

Reasons people report using it; these do not establish benefit.18

Evidence limits

View research →

Long-term effects on healthy adults and reliable clinical benefits for sleep, recovery or longevity remain uncertain.1

2 distinct primary sources or abstracts checked. Evidence may concern a parent compound, individual blend ingredient, animal, or cell model; it does not necessarily establish a benefit for this exact product.

Evidence definitions →

Key safety information

All risks →

Short-lived local effects

Historical diagnostic label reports facial warmth/flushing and injection-site pain.4

Historical Geref approval; discontinued. FDA determined its withdrawal was not for safety or effectiveness reasons.

Molecular information

Amino-acid sequence

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Residue count only · sequence not verified3

An exact sequence has not been verified for this formulation.

Length29 amino acids
Molecular weight · Da3357.9 Da
Formula, sequence notation & identity
Molecular formulaC149H246N44O42S3

Amidated GHRH(1–29).

Formula excludes acetate counterions.

Pharmacokinetics

How long does it stay in the body?

Human data
Reported half-life6–7 minutes (intravenous)4
Route / formulationIntravenous Geref diagnostic injection
Illustrative half-life model for Sermorelin: Human study / labelNormalized terminal-phase decline, not measured blood concentration or effect duration. Five half-lives leaves 3.125%. 0%50%100%07 min14 min21 min28 min35 min1 half-life
50%of reference level

Illustrative model using reported human data.

About 3% remaining after 30 min–35 min

Five half-lives in this simplified model. This is not a prediction of when effects stop.

Evidence and model details

The historical Irish label gives a 6–7-minute range. Illustration uses its 6-minute lower bound. This is not a subcutaneous estimate.

Population: Historical diagnostic-product population; age breakdown not specified

100 × 2−time / half-life. Time zero is a reference level, not the moment of administration. Absorption, repeated dosing, metabolites and clinical effects are not modeled. Five half-lives leaves 3.125%, not zero. This curve cannot determine a dosing interval.

What to expect

Study outcomes

Hormones and function differed

Nighttime GH rose, but IGF-I and body composition did not significantly change; only selected strength/endurance measures improved.1

Reported timelines

Reference & community

Source expectations

IGF-1/sleep 1–2 weeks; composition 2–8; ongoing changes 8–12 weeks to 3–6 months. Anti-aging benefit timeline unvalidated.18

These are reported timelines, not a prediction of your response.

Community poll 10 topics · Pep-Pedia snapshot

Voluntary, unverified reports. These percentages do not measure effectiveness or safety.

Primary goal

Muscle growth34%
Anti-aging19%
Recovery/Healing15%
Fat loss15%
General wellness15%

The source hides 2 additional categories. Their labels and percentages are unavailable.

Number of responses to this question: not disclosed.

Source & limitations

The source displays “664 responses” for this profile. This is not a confirmed participant count or a denominator for individual questions.

  • Voluntary self-reports from Pep-Pedia visitors; identity, treatment, outcomes and timing are unverified. These data are not efficacy or safety estimates.
  • The source displays a profile-wide response label, not a confirmed unique participant count. It stays unchanged across questions. Question-specific denominators and absolute option counts are not exposed.
  • Only the top five categories are displayed for some questions. Extra categories are retained as an undisplayed-category count; their labels and percentages are unavailable.
  • Displayed percentages are rounded. They may not total 100%, especially where categories are hidden.
  • This is a dated snapshot, not a live survey or current recommendation.
Protocols

Doses & schedules

Compare purpose, amount, route, frequency, and duration.

Source corrections

Geref discontinuation does not make compounded products approved; source stack labels are not clinical safety clearance.

9 rows
Route

Scroll to compare all columns →

One row for each documented route and dose or dose range
RouteDoseFrequencyGoal / evidenceDurationReferences
SubQSubcutaneous2 mgNightlyGH secretion and muscle outcomesHuman study6 weeks1
SubQ200-300 mcg dailyOnce at bedtimeAnti-aging/LongevityReference report3-6 months continuous use, then 1-3 month break to prevent desensitization18
SubQ300-500 mcg dailyOnce at bedtimeAthletic PerformanceReference report3-6 months continuous use, then 1-3 month break to prevent desensitization18
SubQ30 mcg/kg dailyOnce at bedtimePediatric GH DeficiencyReference report3-6 months continuous use, then 1-3 month break to prevent desensitization18
IVIV bolus1 mcg/kg IVSingle doseDiagnostic TestingReference report3-6 months continuous use, then 1-3 month break to prevent desensitization18
SubQ200 mcg daily5 days weeklyBody CompositionReference report3-6 months continuous use, then 1-3 month break to prevent desensitization18
SubQSubQ co-injection200 mcg + GHRPOnce dailyCombination TherapyReference report3-6 months continuous use, then 1-3 month break to prevent desensitization18
IntranasalNasal spray or drops30+ mcg/kgOnce dailyAlternative to InjectionReference reportSimilar to injection protocols - 3-6 months18
IntranasalNasal administrationEquivalent to 200-300 mcg SCOnce at bedtimePatient Preference ProtocolReference reportSimilar to injection protocols - 3-6 months18

Study and label doses retain their study context. Reference reports are unvalidated practices, not personal treatment instructions. Ranges remain ranges; escalation stages are labeled.

Cycles & timing

Reference reports18

Reported use periods and breaks. These do not establish a safe cycle or prove that breaks prevent tolerance.

Injectable

Use period
3-6 months continuous use, then 1-3 month break to prevent desensitization
Break
1-3 months off between cycles, or use 5 days on/2 days off schedule
Reported timing

Bedtime administration 2+ hours after last meal for optimal GH response

Nasal

Use period
Similar to injection protocols - 3-6 months
Break
1-3 months between cycles to prevent tolerance
Reported timing

Bedtime administration preferred, ensure clear nasal passages

Side effects & safety

Short-lived local effects

Historical diagnostic label reports facial warmth/flushing and injection-site pain.

4

Contraindications

That label excludes hypersensitivity, pregnancy and lactation.

4

Specialist precautions

Diagnostic use required particular caution in diabetes or epilepsy.

4

Additional reported cautions

Reference reports18

Monitoring

Thyroid function, glucose and IGF-1; local/nasal reactions.

Source exclusions

Active malignancy, pituitary tumors and pregnancy.

Stop symptoms

Headache/vision changes, allergy, severe local reactions, deteriorating glucose control or malignancy-related symptoms.

Not a complete safety screen. Discuss health decisions with a qualified clinician.

Combinations & interactions

10 entries

Check cautions and reported pairings. A compatibility claim does not establish that a combination is safe.

Octreotide

Avoidance reported

Inhibits GH release.18

Reference report · Pep-Pedia label: Avoid Combination

Lanreotide

Avoidance reported

Inhibits GH release.18

Reference report · Pep-Pedia label: Avoid Combination

Prednisone

Caution reported

Can suppress response.18

Reference report · Pep-Pedia label: Use Caution

Insulin

Caution reported

Glucose regulation.18

Reference report · Pep-Pedia label: Monitor Combination

Glucocorticoids, somatostatin or insulin

Label warning

Historical Geref label identifies interference with diagnostic GH responses.4

Research context

Clonidine, levodopa or atropine

Label warning

These can alter the diagnostic response; this is test interpretation, not a general combination-safety endorsement.4

Research context

Ipamorelin

Unverified pairing

GH-axis pairing; benefits not established.18

Reference report · Pep-Pedia label: Synergistic

CJC-1295

Unverified pairing

Overlapping GHRH activity; form matters.18

Reference report · Pep-Pedia label: Synergistic

GHRP-2

Unverified pairing

GH-release potentiation.18

Reference report · Pep-Pedia label: Synergistic

Thyroid hormones

Unverified pairing

Replacement only when indicated.18

Reference report · Pep-Pedia label: Compatible

Reconstitution calculator

Enter your peptide amount and container size. Get a volume and a simple measurement scale.

mg

Total labeled amount of Sermorelin.

mL

Usable capacity of the destination vial or pen cartridge.

1 dial unit = 0.01 mL on the documented V2 model. Confirm your pen’s scale.

Vial examples & blend contents Sermorelin

Listed amounts are packaging examples. Check your actual label.

Reconstitution

Historical formulation only

Historical Geref 50 instructions do not validate modern research powders.4

Diagnostic ampoule

The 50-mcg ampoule used at least 0.5 mL supplied 0.9% saline immediately before use; remainder discarded.4

Reference preparation details

Reported handling information, not a validated formulation or instruction to prepare an injectable product.

Injectable

Pep-Pedia names 3 mL BAC water but does not attach a vial mass to that volume.

Solvents mentioned
Bacteriostatic water
Reported parameters
A concentration cannot be inferred from 3 mL alone. · Reported storage: 2–8°C for 10–30 days, depending on formulation.

The source describes gentle mixing and avoiding vigorous shaking.

Nasal

The nasal section emphasizes device calibration and refrigerated storage.

Reported parameters
It gives no numerical concentration or storage interval.
18
Appearance & documentation

Appearance and a purity certificate cannot establish sterility, identity, or suitability for injection.

Reported appearanceClear reconstituted solutionReported appearancePharmaceutical grade purityReported appearanceProper cold chain storageReported appearanceFDA-registered manufacturingReported concernCloudy or discolored solutionReported concernIncorrect molecular weightReported variationRoom temperature exposure
18

Vial sizes

5mg6

Packaging examples, not a market survey. Approved and research products are not interchangeable.

Storage after mixing

Reconstituted research vials

Pep-Pedia reports these handling limits after mixing. They are not validated stability or sterility limits for your vial.

Injectable

Unverified report18
10–30 days2–8°C
Full storage notes from Pep-Pedia18
Injectable

Lyophilized: 2-8°C up to 3 years; Reconstituted: 2-8°C for 10-30 days

Nasal

Refrigerate nasal formulations, protect from light

Storage depends on the formulation, diluent, container, and handling. Follow the specific product label or pharmacist’s instructions.

Pen & syringe measurements Scales, capacity & references

Pen & syringe measurements

Device units measure volume. Concentration determines the amount in mg.

Open calculator ↗
V2 peptide pen

1 notch = 0.01 mL

Documented 1-unit V2 models

One dial increment
1 unit
Cartridge capacity
3 mL
Maximum setting
60 units · 0.60 mL

Use the numbered dose window. Whole-unit settings only; confirm the specification for your exact model.

U-100 syringe

1 unit = 0.01 mL

100 units = 1 mL

10 units
0.10 mL
30-unit capacity
0.30 mL
50 / 100-unit capacity
0.50 / 1 mL

Read the printed unit scale. A small line may represent 0.5, 1, or 2 units depending on the syringe.

Other measuring tools

Use the mL scale

mL syringes and calibrated pipettes

0.01 mL
10 µL
0.10 mL
100 µL
Amount
mL × mg/mL

Drops, sprays and other pen clicks need their own verified volume per increment. They have no universal conversion.

3 mL is cartridge capacity. It does not mean you must prepare or load 3 mL. The original vial and the pen cartridge are different containers. This reference compares measurement scales; it does not establish product or route compatibility.

Device referencesAVERON V2 specifications ↗SilverLeaf V2 unit reference ↗FDA: syringe unit conversions ↗Specifications checked October 12, 2026.

Research findings

Limited human data

Source context

Geref discontinuation does not make compounded products approved; source stack labels are not clinical safety clearance.

Compound identity & other names

A GHRH fragment that stimulates growth-hormone release. Geref was previously approved and later discontinued; today's compounded or research products should not be presented as the historical approved product.

Other names: GHRH 1-29 · Geref

Historical Geref approval; discontinued. FDA determined its withdrawal was not for safety or effectiveness reasons.

How it may work

Pituitary GHRH receptors stimulate pulsatile GH and downstream IGF-1.18

Hormone response and clinical outcomes

A small study of nightly GHRH(1-29) in older men found increased nocturnal GH but no change in IGF-I. Some strength measures improved; that does not establish broad anti-aging benefit.

1

Historical approval and discontinuation

FDA's 2013 notice found Geref products were not removed from sale for reasons of safety or effectiveness. This does not approve new sellers or longevity claims.

2
Research areas and evidence gaps

GH secretion research. Small studies examined hormone and functional responses in older men.1

Historical diagnostic use. Geref evaluated pituitary GH reserve under specialist supervision.4

  • Long-term effects on healthy adults and reliable clinical benefits for sleep, recovery or longevity remain uncertain.
  • Results from related modified GHRH analogues should not automatically be assigned to sermorelin.
Community reports Unvalidated

Pep-Pedia describes sleep, recovery and body-composition expectations. These are secondary community claims, not established long-term clinical outcomes.5

A secondary protocol description, not a clinical recommendation or a representative survey. Dose, product identity, other compounds and outcome reporting are not independently verified.

Search coverage and review status

No additional 2025–2026 peer-reviewed efficacy trial of this exact product was identified in this targeted check. Earlier evidence and unresolved listed references are retained.

Checked
2026-10-12
Search
sermorelin 2025 2026 trial site:pubmed.ncbi.nlm.nih.gov
Catalog
Pep-Pedia ↗ · 10 listed references retained
  • Targeted search, not an exhaustive systematic review.
  • Bibliography-only entries are retained for traceability and are not treated as verified findings.
  • Pep-Pedia maps nasal-administration and combination-study labels to a commentary/review; those claims are not independently verified.
  • Citation mismatch: the listed GHRH study title corresponds to PMID 9005976, while Pep-Pedia links PMID 9005977.

AI-prepared summaries. Independent medical editorial review is pending.

References

Original sources and review status. Open a reference to read its summary.

18 sources

1Nightly GHRH(1-29) in healthy elderly menTrial · 1997 · pubmed.ncbi.nlm.nih.govReview status not recorded
AI-PREPARED SUMMARY

Exploratory study reported more nocturnal GH without higher IGF-I and improvements in selected strength measures. It does not establish longevity benefits.

Hormone response and clinical outcomes

A small study of nightly GHRH(1-29) in older men found increased nocturnal GH but no change in IGF-I. Some strength measures improved; that does not establish broad anti-aging benefit.

Original source
2FDA determination on discontinued GerefRegulator · 2013 · govinfo.govReview status not recorded
AI-PREPARED SUMMARY

FDA determined Geref's discontinued products had not been withdrawn for safety or effectiveness reasons.

Historical approval and discontinuation

FDA's 2013 notice found Geref products were not removed from sale for reasons of safety or effectiveness. This does not approve new sellers or longevity claims.

Original source
3PubChem: sermorelin chemical identityRegistry · 2026 · pubchem.ncbi.nlm.nih.govReview status not recorded
AI-PREPARED SUMMARY

Records amidated GHRH(1–29), its molecular formula and molecular weight.

Original source
4Historical Irish Geref 50 product characteristicsRegulator · 2006 · assets.hpra.ieReview status not recorded
AI-PREPARED SUMMARY

Historical diagnostic label with IV half-life, test interactions and formulation-specific saline preparation. It is not a current US research-powder label.

Original source
5Pep-Pedia: sermorelin — community referenceCommunity · 2026 · pep-pedia.orgCommunity source checked
AI-PREPARED SUMMARY

Accessed October 12, 2026. Reports commonly discussed protocols; these schedules are unvalidated descriptions, not evidence of safety or efficacy.

Original source
6Research catalog: labeled vial examplesCatalog · 2026 · peptalabs.comCatalog checked
AI-PREPARED SUMMARY

Catalog lists a 5 mg research vial. These are seller label examples, not verified contents, market-frequency estimates or supplier endorsements.

Original source
7Nasal Administration Study (1990s)Pep-Pedia maps nasal-administration and combination-study labels to a commentary/review; those claims are not independently verified.Research reference · Accessed 2026 · pubmed.ncbi.nlm.nih.govPep-Pedia report · Primary source not checked
AI-PREPARED SUMMARY

Pep-Pedia reports: The source describes nasal GHRH delivery and 69% preference for it; exact analogue, exposure and comparator need checking.

Reported population / model
Adults

Reported study details
30+ μg/kg intranasal · Acute · 69% patient preference over injection · Additional card metadata — Synergistic Effects with GHRP-2 (Clinical): Adults·GHRH+GHRP-2·Acute·54-fold vs 20-fold GH increase

Synergistic Effects with GHRP-2 (Clinical): Combined GHRH/GHRP-2 reportedly produced larger acute GH release; this is not direct evidence for every sermorelin combination or chronic outcome.

Reported by Pep-Pedia; the linked publication, design, doses and result have not been independently verified here. Pep-Pedia maps nasal-administration and combination-study labels to a commentary/review; those claims are not independently verified. Multiple reference cards share this URL; their attribution may differ.

Read the Pep-Pedia report ↗

Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12

Listed study
8Daily GHRH-(1-29) in GH-deficient children: first-year Geref study (1996)Pep-Pedia also assigns adult pharmacokinetic claims to this URL; the abstract concerns pediatric growth treatment.Trial · 1996 · pubmed.ncbi.nlm.nih.govAbstract checked
AI-PREPARED SUMMARY

An open-label study treated 110 GH-deficient children with 30 micrograms/kg subcutaneously each evening for up to one year; 86 entered the efficacy analysis. Mean growth velocity rose from 4.1 to 8.0 cm/year at six months and 7.2 at twelve months. This paper is not an adult pharmacokinetic study and does not report 36 months of treatment.

Primary abstract checked during reference-card audit · Checked 2026-10-12

Original source
9GHRH-(1-29) hormone responses in older men (1992)The reference page combines six-week and body-composition descriptions under this URL; the checked abstract describes two 14-day courses.Trial · 1992 · pubmed.ncbi.nlm.nih.govAbstract checked
AI-PREPARED SUMMARY

Ten older men received 0.5 mg and 1 mg GHRH-(1-29) subcutaneously twice daily, each for 14 days with a 14-day untreated interval. The higher dose raised GH and IGF-I toward young-comparator values. Blood pressure did not change; the abstract did not demonstrate the separate 1.26 kg lean-mass claim assigned to this URL.

Primary abstract checked during reference-card audit · Checked 2026-10-12

Original source
10Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiencyReview · Accessed 2026 · pubmed.ncbi.nlm.nih.govLinked reference · Not independently reviewed
REFERENCE NOTE

Listed in Pep-Pedia’s bibliography; the linked publication and its findings have not been independently verified in this pass.

Pep-Pedia bibliography · Checked 2026-10-12

Listed source
11A potentially effective drug for patients with recurrent glioma: sermorelinResearch reference · Accessed 2026 · pubmed.ncbi.nlm.nih.govLinked reference · Not independently reviewed
REFERENCE NOTE

Listed in Pep-Pedia’s bibliography; the linked publication and its findings have not been independently verified in this pass.

Pep-Pedia bibliography · Checked 2026-10-12

Listed source
12Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal malesResearch reference · Accessed 2026 · pubmed.ncbi.nlm.nih.govLinked reference · Not independently reviewed
REFERENCE NOTE

Listed in Pep-Pedia’s bibliography; the linked publication and its findings have not been independently verified in this pass.

Pep-Pedia bibliography · Checked 2026-10-12

Listed source
13Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly menCitation mismatch: the listed GHRH study title corresponds to PMID 9005976, while Pep-Pedia links PMID 9005977.Research reference · Accessed 2026 · pubmed.ncbi.nlm.nih.govLinked reference · Not independently reviewed
REFERENCE NOTE

Pep-Pedia bibliography retained as listed. The correctly linked study is separately included as “Nightly GHRH(1-29) in healthy elderly men.”

Pep-Pedia bibliography · Checked 2026-10-12

Listed source
14Growth hormone-releasing hormone therapy in growth hormone-deficient children: Geref International Study GroupResearch reference · Accessed 2026 · pubmed.ncbi.nlm.nih.govLinked reference · Not independently reviewed
REFERENCE NOTE

Listed in Pep-Pedia’s bibliography; the linked publication and its findings have not been independently verified in this pass.

Pep-Pedia bibliography · Checked 2026-10-12

Listed source
15Growth hormone secretagogues: history, mechanism of action, and clinical developmentResearch reference · Accessed 2026 · onlinelibrary.wiley.comLinked reference · Not independently reviewed
REFERENCE NOTE

Listed in Pep-Pedia’s bibliography; the linked publication and its findings have not been independently verified in this pass.

Pep-Pedia bibliography · Checked 2026-10-12

Listed source
16Sermorelin acetate discontinuation - manufacturing, not safety relatedRegulator · Accessed 2026 · fda.govLinked reference · Not independently reviewed
REFERENCE NOTE

Listed in Pep-Pedia’s bibliography; the linked publication and its findings have not been independently verified in this pass.

Pep-Pedia bibliography · Checked 2026-10-12

Listed source
17Pep-Pedia: Sermorelin — reported pharmacokineticsReference estimate; not independently verified human PKCommunity · 2026 · pep-pedia.orgCommunity source checked
AI-PREPARED SUMMARY

Lists a half-life of 12 min and a peak time of 10 min. Stated attribution: FDA Geref Label (discontinued). The checked IV Geref label gives 6–7 minutes; the reference value is retained separately and must not replace route-specific label data. Five half-lives is not complete clearance, and the source’s “cleared” value is not used as a measured endpoint.

Secondary reference page checked; the underlying quantitative claim is not independently confirmed. · Checked 2026-10-12

Original source
18Pep-Pedia: Sermorelin — route-specific referenceReference page checked; underlying claims require separate verification.Community · Checked 2026 · pep-pedia.orgCommunity source checked
AI-PREPARED SUMMARY

Source page checked across available routes. Protocols, cycles, storage, mechanisms and pairing claims are secondary reports; checking the page does not independently validate those claims. Original concise summaries are used here.

Content coverage audit · Checked 2026-10-12

Original source
Source details