ERR and exercise biology
2Preclinical chemical probe.
MetabolicSmall molecule
SLU-PP-332
Pan-estrogen-related receptor (ERRα/β/γ) agonist
Lab studiesExercise-related metabolism2
Preclinical research chemical; no verified human therapeutic formulation.
What does it do?
A small-molecule ERR agonist studied as an exercise mimetic in animals; it is not a peptide or established human therapy.
Approved & studied uses
Community uses Reported, unvalidated
Metabolic
10Adiposity, glucose, liver-fat and energy-expenditure models.
Performance
10Endurance, oxidative muscle remodeling and mitochondrial capacity.
Organ / aging
10Cardiac, kidney, inflammatory, oxidative-stress and cellular-aging research.
Reasons people report using it; these do not establish benefit.10
Evidence limits
View research →Research-market product identity, purity and formulation cannot be established from a publication.2
3 distinct primary sources or abstracts checked. Evidence may concern a parent compound, individual blend ingredient, animal, or cell model; it does not necessarily establish a benefit for this exact product.
Evidence definitions →Key safety information
All risks →Human safety is unresolved
The checked material does not establish a human adverse-event rate or safe self-use regimen for this exact product.4
Preclinical research chemical; no verified human therapeutic formulation.
Amino-acid sequence
An exact sequence has not been verified for this formulation.
Reference identity · not independently confirmed10
LengthNon-peptide small molecule
Molecular weight · Da290.32 Da
Formula, sequence notation & identity
Pan-estrogen-related receptor (ERRα/β/γ) agonist
Salt, hydration, glycosylation and blend composition may change the supplied material; no unsupported formula or mass is assigned.
Pep-Pedia identity details
Non-peptide small molecule · 290.32 Da
Not applicable - synthetic small moleculeReference description; checked chemical identity above takes precedence when available.10
Pharmacokinetics
How long does it stay in the body?
Reported half-lifeNo verified human estimate4
No numerical curve is shown without an exact compound, formulation and human-route match.
No numerical estimate was found in the checked data or Pep-Pedia profile. A curve would require an unsupported assumption.
What to expect
Study outcomes
Exercise effects were measured in mice
SLU-PP-332 increased oxidative muscle fibers and treadmill endurance in mice. Human exercise capacity, toxicity and dosing remain unverified.2
2026 human-liver work is in vitro
The metabolite study used liver fractions outside the body. It cannot supply a human plasma half-life or safe dose.3
Reported timelines
Reference & communityAnimal timing
Transcription/metabolism hours; adaptations week 1; endurance/adiposity 2–4 weeks; organ changes 6–8 weeks; aging studies months.10
Human timing
No validated response, persistence or tolerance timeline.10
These are reported timelines, not a prediction of your response.
Community poll 10 topics · Pep-Pedia snapshot
Voluntary, unverified reports. These percentages do not measure effectiveness or safety.
Experience
Number of responses to this question: not disclosed.
Duration of use
Number of responses to this question: not disclosed.
Age range
The source hides 1 additional categories. Their labels and percentages are unavailable.
Number of responses to this question: not disclosed.
Gender
Number of responses to this question: not disclosed.
Primary goal
The source hides 6 additional categories. Their labels and percentages are unavailable.
Number of responses to this question: not disclosed.
Effectiveness
The source hides 9 additional categories. Their labels and percentages are unavailable.
Number of responses to this question: not disclosed.
Side effects
The source hides 4 additional categories. Their labels and percentages are unavailable.
Number of responses to this question: not disclosed.
Dosage frequency
Number of responses to this question: not disclosed.
Would recommend
The source hides 2 additional categories. Their labels and percentages are unavailable.
Number of responses to this question: not disclosed.
How discovered
The source hides 1 additional categories. Their labels and percentages are unavailable.
Number of responses to this question: not disclosed.
Source & limitations
The source displays “531 responses” for this profile. This is not a confirmed participant count or a denominator for individual questions.
- Voluntary self-reports from Pep-Pedia visitors; identity, treatment, outcomes and timing are unverified. These data are not efficacy or safety estimates.
- The source displays a profile-wide response label, not a confirmed unique participant count. It stays unchanged across questions. Question-specific denominators and absolute option counts are not exposed.
- Only the top five categories are displayed for some questions. Extra categories are retained as an undisplayed-category count; their labels and percentages are unavailable.
- Displayed percentages are rounded. They may not total 100%, especially where categories are hidden.
- This is a dated snapshot, not a live survey or current recommendation.
Protocols
Doses & schedules
Compare purpose, amount, route, frequency, and duration.
Source corrections
Rodent weight-loss/endurance percentages are not human forecasts. Source compatibility labels are not combination safety evidence.
Route
Scroll to compare all columns →
| Route | Dose | Frequency | Goal / evidence | Duration | References |
|---|---|---|---|---|---|
| OtherIP | 50 mg/kg (animal dosing) | Twice daily | RESEARCH USE ONLY - Standard metabolic protocolReference report | Not specified | 10 |
Population Population not independently verified; see the reference and linked research. Context Reported in Pep-Pedia’s educational protocol table. Study attribution and applicability to this exact product are not independently established. Rodent weight-loss/endurance percentages are not human forecasts. Source compatibility labels are not combination safety evidence. Source tabs Injectable | |||||
| OtherIP | 50 mg/kg (animal dosing) | Single dose 1 hour pre-exercise | RESEARCH USE ONLY - Acute exercise enhancementReference report | Not specified | 10 |
Population Population not independently verified; see the reference and linked research. Context Reported in Pep-Pedia’s educational protocol table. Study attribution and applicability to this exact product are not independently established. Rodent weight-loss/endurance percentages are not human forecasts. Source compatibility labels are not combination safety evidence. Source tabs Injectable | |||||
| OtherIP | 50 mg/kg (animal dosing) | Twice daily for 4-8 weeks | RESEARCH USE ONLY - Extended treatmentReference report | Not specified | 10 |
Population Population not independently verified; see the reference and linked research. Context Reported in Pep-Pedia’s educational protocol table. Study attribution and applicability to this exact product are not independently established. Rodent weight-loss/endurance percentages are not human forecasts. Source compatibility labels are not combination safety evidence. Source tabs Injectable | |||||
| OralOral formulation in development | No approved human dose | Awaiting clinical trials | HUMAN DOSING NOT ESTABLISHEDReference report | Not specified | 10 |
Population Population not independently verified; see the reference and linked research. Context Reported in Pep-Pedia’s educational protocol table. Study attribution and applicability to this exact product are not independently established. Rodent weight-loss/endurance percentages are not human forecasts. Source compatibility labels are not combination safety evidence. Source tabs Injectable | |||||
No protocols match these filters.
Study and label doses retain their study context. Reference reports are unvalidated practices, not personal treatment instructions. Ranges remain ranges; escalation stages are labeled.
Reported use periods and breaks. These do not establish a safe cycle or prove that breaks prevent tolerance.
Injectable
- Use period
- NOT ESTABLISHED - animal studies used 4-8 weeks
- Break
- UNKNOWN - no human data available
Reported timing
Awaiting human clinical trials
Side effects & safety
Human safety is unresolved
The checked material does not establish a human adverse-event rate or safe self-use regimen for this exact product.
4Unknown safety
Animal tolerability cannot establish human safety, reproductive effects or chronic exposure risks.
Urgent
Hypoglycemia, chest pain, palpitations, dyspnea, jaundice/dark urine, reduced urination/edema, severe headache or allergy.
Not a complete safety screen. Discuss health decisions with a qualified clinician.
Combinations & interactions
9 entriesCheck cautions and reported pairings. A compatibility claim does not establish that a combination is safe.
Metformin
Caution reportedMetabolic overlap.10
Reference report · Pep-Pedia label: Monitor CombinationInsulin
Caution reportedGlucose effects.10
Reference report · Pep-Pedia label: Monitor CombinationTirzepatide
Caution reportedUntested metabolic pairing.10
Reference report · Pep-Pedia label: Monitor CombinationSemaglutide
Caution reportedUntested metabolic pairing.10
Reference report · Pep-Pedia label: Monitor Combination5-Amino-1MQ
Unverified pairingUntested pairing.10
Reference report · Pep-Pedia label: CompatibleNAD+
Unverified pairingUnproven mitochondrial stack.10
Reference report · Pep-Pedia label: SynergisticCJC-1295
Unverified pairingUntested pairing.10
Reference report · Pep-Pedia label: CompatibleIpamorelin
Unverified pairingUntested pairing.10
Reference report · Pep-Pedia label: CompatibleOther medicines and research compounds
Not establishedNo clinical interaction study for the exact proposed combination was verified; absence of evidence does not establish compatibility.4
Research contextNo matching interactions. Try another name or filter.
Reconstitution
No universal bacteriostatic-water volume or validated preparation method is established for this entry.4
Reference preparation details
Reported handling information, not a validated formulation or instruction to prepare an injectable product.
Injectable
The source reports laboratory vehicles for a water-insoluble small molecule, not a human peptide preparation.
- Solvents mentioned
- DMSO — laboratory stock / Tween 80 / PBS / PEG300 / Saline / Corn oil
- Reported parameters
- Reported DMSO stock: 50–125 mg/mL. · Reported experimental vehicles: 10% DMSO/10% Tween 80/80% PBS; 10% DMSO/40% PEG300/5% Tween 80/45% saline; or 10% DMSO/90% corn oil. · Reported stock storage: −80°C for 6 months or −20°C for 1 month; avoid repeated freeze–thaw.
The source says BAC water is unsuitable and describes at most 10% final DMSO for its experiments; this does not establish safety for human administration.
Appearance & documentation
Appearance and a purity certificate cannot establish sterility, identity, or suitability for injection.
Reported concernInsoluble in water - use DMSOReported variationResearch Chemical Only - NOT FOR HUMAN USEReported concernProducts Marketed for Human ConsumptionReported concernUnknown Purity or ContaminationReported variationNo Quality Control Standards ExistReported appearanceLegitimate Research Supplier
10Available forms
No verified packaging examples included.
Packaging examples, not a market survey. Approved and research products are not interchangeable.
Storage after mixing
Reconstituted research vials
Refrigerated lifetime not established
The checked sources do not establish how long this research preparation remains stable and sterile after mixing.10
Storage depends on the formulation, diluent, container, and handling. Follow the specific product label or pharmacist’s instructions.
Research findings
PreclinicalSource context
Rodent weight-loss/endurance percentages are not human forecasts. Source compatibility labels are not combination safety evidence.
Compound identity & other names
A laboratory chemical probe that affects exercise-related gene programs in mice. No verified human dosing or clinical benefit is established in the checked sources.
Preclinical research chemical; no verified human therapeutic formulation.
How it may work
ERR-driven transcription regulates oxidative metabolism, mitochondrial biogenesis and fatty-acid use.10
Exercise effects were measured in mice
SLU-PP-332 increased oxidative muscle fibers and treadmill endurance in mice. Human exercise capacity, toxicity and dosing remain unverified.
22026 human-liver work is in vitro
The metabolite study used liver fractions outside the body. It cannot supply a human plasma half-life or safe dose.
3Research areas and evidence gaps
ERR and exercise biology. Preclinical chemical probe.2
- Research-market product identity, purity and formulation cannot be established from a publication.
Community reports Unvalidated
Pep-Pedia describes community interest and schedules; these are secondary reports, not measured clinical outcomes.4
No representative survey, independently verified products, or controlled outcomes.
Search coverage and review status
The targeted check identified relevant additional literature or current regulatory information; checked findings are separated from retained bibliography-only references.
- Checked
- 2026-10-12
- Search
- "SLU-PP-332" 2026 2025 site:pubmed.ncbi.nlm.nih.gov
- Catalog
- Pep-Pedia ↗ · 6 listed references retained
- Targeted search, not an exhaustive systematic review.
- Bibliography-only entries are retained for traceability and are not treated as verified findings.
AI-prepared summaries. Independent medical editorial review is pending.
References
Original sources and review status. Open a reference to read its summary.
1Synthetic ERRα/β/γ Agonist Induces Acute Aerobic Exercise Response - 2023Abstract checked
AI-PREPARED SUMMARY
Cell and mouse experiments found increased mitochondrial respiration and exercise endurance; no human study.
Pep-Pedia bibliography · Checked 2026-10-12
2SLU-PP-332 induces an ERR-dependent exercise responseAbstract checked
AI-PREPARED SUMMARY
Cell and mouse experiments found increased mitochondrial respiration and exercise endurance; no human study.
Exercise effects were measured in mice
SLU-PP-332 increased oxidative muscle fibers and treadmill endurance in mice. Human exercise capacity, toxicity and dosing remain unverified.
Additional research · Checked 2026-10-12
3In-vitro metabolites of SLU-PP-332 for doping-control purposesAbstract checked
AI-PREPARED SUMMARY
Human liver S9 fractions generated candidate metabolites for analytical detection. This is not an in-vivo human PK or safety study.
2026 human-liver work is in vitro
The metabolite study used liver fractions outside the body. It cannot supply a human plasma half-life or safe dose.
Additional research · Checked 2026-10-12
4Pep-Pedia: SLU-PP-332 — community referenceCommunity source checked
AI-PREPARED SUMMARY
Accessed October 12, 2026. Secondary descriptions and bibliography; community schedules are unvalidated reports, not recommendations.
5A Synthetic ERR Agonist Alleviates Metabolic Syndrome - 2024Pep-Pedia report · Primary source not checked
AI-PREPARED SUMMARY
Pep-Pedia reports: Obese mice showed less weight/fat accumulation, greater fat oxidation and improved glucose/liver-fat measures; human benefit is not established.
Reported population / model
Diet-induced obese mice
Reported study details
50 mg/kg IP twice daily · 28 days · Comprehensive metabolic assessment
Reported by Pep-Pedia; the linked publication, design, doses and result have not been independently verified here.
Read the Pep-Pedia report ↗Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12
6Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction in Aging Kidney - 2023Pep-Pedia report · Primary source not checked
AI-PREPARED SUMMARY
Pep-Pedia reports: Aged-mouse kidney findings included less albuminuria and preserved mitochondrial/podocyte structure; claims of general age reversal exceed the measured endpoints.
Reported population / model
21-month-old mice (equivalent to ~60-70 human years)
Reported study details
8-week treatment · Comprehensive kidney function analysis
Reported by Pep-Pedia; the linked publication, design, doses and result have not been independently verified here.
Read the Pep-Pedia report ↗Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12
7Mitochondrial Biogenesis and Metabolic Remodeling Study - 2023Pep-Pedia report · Primary source not checked
AI-PREPARED SUMMARY
Pep-Pedia reports: The source describes skeletal-muscle mitochondrial and oxidative-gene changes; these are mechanistic findings rather than human performance results.
Reported population / model
Skeletal muscle analysis
Reported study details
Multiple time points · Gene expression and mitochondrial function
Pep-Pedia supplies no original study link for this card. Study identity, design, doses and result remain unverified.
Read the Pep-Pedia report ↗Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12
8Cardiac Protective Effects of Pan-ERR Agonists - 2021Pep-Pedia report · Primary source not checked
AI-PREPARED SUMMARY
Pep-Pedia reports: Pan-ERR agonists improved cardiac function and fibrosis in animal failure models; the exact compound and final publication need checking.
Reported population / model
Heart failure models
Reported study details
6-week treatment · Cardiac function and structural analysis
Reported by Pep-Pedia; the linked publication, design, doses and result have not been independently verified here.
Read the Pep-Pedia report ↗Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12
9Safety and Toxicology Profiling - OngoingPep-Pedia report · Primary source not checked
AI-PREPARED SUMMARY
Pep-Pedia reports: The card makes broad multi-species toxicology claims without a linked report; absence of organ toxicity cannot be assumed from this summary.
Reported population / model
Multiple species (rodents, canines)
Reported study details
Various doses and durations · Comprehensive toxicology
Pep-Pedia supplies no original study link for this card. Study identity, design, doses and result remain unverified.
Read the Pep-Pedia report ↗Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12
10Pep-Pedia: SLU-PP-332 — route-specific referenceReference page checked; underlying claims require separate verification.Community source checked
AI-PREPARED SUMMARY
Source page checked across available routes. Protocols, cycles, storage, mechanisms and pairing claims are secondary reports; checking the page does not independently validate those claims. Original concise summaries are used here.
Content coverage audit · Checked 2026-10-12