Skin & hair

Melanotan II

Melanocortin receptor agonist

Studied forSexual response1
Community reportsTanning · pigmentation16

No FDA-approved Melanotan II product. Afamelanotide/Scenesse approval does not apply to Melanotan II.

What does it do?

Unapproved melanocortin agonist used in community tanning/sexual-function practices. Nasal and topical products lack established human efficacy or dosing equivalence.

Approved & studied uses

Sexual effects

1

Spontaneous erections were observed in the pilot; this is not an approved treatment indication.

Community uses Reported, unvalidated

Pigmentation

15

Tanning and localized/vitiligo claims; not proven UV protection.

Sexual response

15

Libido/arousal/erection effects, with priapism risk.

Appetite/metabolism

15

Appetite, fat/glucose claims require stronger clinical evidence.

Reasons people report using it; these do not establish benefit.15

Evidence limits

View research →

Long-term risk, reliable product quality, and benefit-risk balance for tanning.1

5 distinct primary sources or abstracts checked. Evidence may concern a parent compound, individual blend ingredient, animal, or cell model; it does not necessarily establish a benefit for this exact product.

Evidence definitions →

Key safety information

All risks →

Nausea and fatigue

The pilot reported nausea at most dose levels; fatigue or sleepiness occurred at higher doses.1

No FDA-approved Melanotan II product. Afamelanotide/Scenesse approval does not apply to Melanotan II.

Molecular information

Amino-acid sequence

  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  6. 6
  7. 7

Residue count only · sequence not verified4

An exact sequence has not been verified for this formulation.

Length7 amino acids
Molecular weight · Da1024.2 Da
Formula, sequence notation & identity
Molecular formulaC50H69N15O94

Melanotan II, a cyclic, acetylated melanocortin analog with an amidated terminus.

Parent-peptide identity; a salt or formulated product can have a different total mass.

Pharmacokinetics

How long does it stay in the body?

Class inferenceNot independently confirmed
Reference half-life1 hour14
Route / formulationSource page: Injectable. Exact PK route not verified.

The source identifies this as a class-level inference, not a measured half-life for this compound. Pep-Pedia identifies this as a class inference from human melanotan-I data. It is not a measured melanotan-II half-life.

Illustrative half-life model for Melanotan II: Pep-Pedia estimateNormalized terminal-phase decline, not measured blood concentration or effect duration. Five half-lives leaves 3.125%. 0%50%100%01 h2 h3 h4 h5 h1 half-life
50%of reference level

Illustrative scenario using an unverified reference estimate.

About 3% remaining after 5 h

Five half-lives in this estimated model. This is not a prediction of when effects stop.

Evidence and model details

Population: Not established by the reference estimate

Source’s stated attribution: Dorr et al. 1996 J Natl Cancer Inst 88(17):1196-1201 (MT-I human subQ PK; class inference applied to MT-II)

Source’s reported peak time: 30 min. This has not been independently confirmed and is not used in the elimination curve.

100 × 2−time / half-life. Time zero is a reference level, not the moment of administration. Absorption, repeated dosing, metabolites and clinical effects are not modeled. Five half-lives leaves 3.125%, not zero. This curve cannot determine a dosing interval.

What to expect

Study outcomes

Very small pigmentation signal

Two of three volunteers had increased pigmentation one week after the pilot course. The sample cannot establish a reliable expected response.1

Reported timelines

Reference & community

Injection: days 1–7; weeks 1–4+

Reported GI/arousal then pigment changes.15

Topical: weeks 2–8+; nasal: weeks 1–4+

Source claims, not validated timelines.15

These are reported timelines, not a prediction of your response.

Community poll 10 topics · Pep-Pedia snapshot

Voluntary, unverified reports. These percentages do not measure effectiveness or safety.

Primary goal

Other: Tanning27%
Other: Tan15%
General wellness10%
Other: Tanning 10%
Other (please specify)6%

The source hides 38 additional categories. Their labels and percentages are unavailable.

Number of responses to this question: not disclosed.

Source & limitations

The source displays “1596 responses” for this profile. This is not a confirmed participant count or a denominator for individual questions.

  • Voluntary self-reports from Pep-Pedia visitors; identity, treatment, outcomes and timing are unverified. These data are not efficacy or safety estimates.
  • The source displays a profile-wide response label, not a confirmed unique participant count. It stays unchanged across questions. Question-specific denominators and absolute option counts are not exposed.
  • Only the top five categories are displayed for some questions. Extra categories are retained as an undisplayed-category count; their labels and percentages are unavailable.
  • Displayed percentages are rounded. They may not total 100%, especially where categories are hidden.
  • This is a dated snapshot, not a live survey or current recommendation.
Protocols

Doses & schedules

Compare purpose, amount, route, frequency, and duration.

Source corrections

Source compatibility/photoprotection claims do not establish safety; tanning does not remove UV risk.

14 rows
Route

Scroll to compare all columns →

One row for each documented route and dose or dose range
RouteDoseFrequencyGoal / evidenceDurationReferences
SubQSubcutaneous injection0.01 mg/kg — initial exposureInitial active doseAssess tanning and acute tolerabilityHuman study2 weeks1
SubQSubcutaneous injection0.025 mg/kg — escalation endpointAfter 0.005 mg/kg escalation stepsAssess tanning and acute tolerabilityHuman study2 weeks1
SubQSubcutaneous injection0.03 mg/kg — escalation endpointAfter 0.005 mg/kg escalation stepsAssess tanning and acute tolerabilityHuman study2 weeks1
SubQ0.25 mgDailyInitial LoadingReference report4-8 weeks on, 4 weeks off15
SubQ0.5-1 mg2-3x weeklyTanning MaintenanceReference report4-8 weeks on, 4 weeks off15
SubQ0.5-1 mgAs neededSexual EnhancementReference report4-8 weeks on, 4 weeks off15
SubQ0.1-0.25 mgEvery other dayMinimal Side EffectsReference report4-8 weeks on, 4 weeks off15
SubQ0.5 mg2x weeklyPhotoprotectionReference report4-8 weeks on, 4 weeks off15
TopicalTopical cream0.5-1 mg/mlOnce dailyFacial TanningReference report6-12 weeks continuous use15
TopicalTopical solution1-2 mg/mlTwice dailyBody ApplicationReference report6-12 weeks continuous use15
TopicalTopical + UV2 mg/mlTwice dailyVitiligo PatchesReference report6-12 weeks continuous use15
IntranasalNasal spray0.5 mgOnce dailyInitial ToleranceReference report4-6 weeks15
IntranasalNasal spray1 mgDaily or as neededStandard ProtocolReference report4-6 weeks15
IntranasalNasal spray1-2 mg2-3x weeklyMaintenanceReference report4-6 weeks15

Study and label doses retain their study context. Reference reports are unvalidated practices, not personal treatment instructions. Ranges remain ranges; escalation stages are labeled.

Cycles & timing

Reference reports15

Reported use periods and breaks. These do not establish a safe cycle or prove that breaks prevent tolerance.

Injectable

Use period
4-8 weeks on, 4 weeks off
Break
4 weeks minimum to assess melanin fading
Reported timing

Morning for tanning effects, evening for sexual effects (or 2-4 hours before)

Topical

Use period
6-12 weeks continuous use
Break
4-6 weeks to assess results
Reported timing

Apply to clean skin, allow to absorb before sun exposure

Nasal

Use period
4-6 weeks
Break
4 weeks between cycles
Reported timing

Morning for tanning, 1-2 hours before for sexual effects

Side effects & safety

Nausea and fatigue

The pilot reported nausea at most dose levels; fatigue or sleepiness occurred at higher doses.

1

Prolonged erections

The pilot observed intermittent erections over 1–5 hours after dosing; FDA also cites published priapism reports.

12

Serious case reports

FDA lists reports including melanoma, neurologic illness and sympathomimetic toxicity. Reports do not establish incidence or prove causation.

2

Product uncertainty

FDA flags immune-reaction risks associated with peptide aggregation and impurities in compounded products.

2

Oral pigmentation

A case report found persistent gum discoloration after discontinuation; this was pigmentation, not a diagnosis of melanoma.

5

Additional reported cautions

Reference reports15

Systemic effects

Nausea, flushing, fatigue, headache and blood-pressure changes; changing moles require assessment.

Urgent symptoms

Painful prolonged erection, chest pain, severe headache/vision change, persistent vomiting or allergy.

Local routes

Skin irritation/patchy pigment; nasal bleeding, infection, smell loss or congestion.

Not a complete safety screen. Discuss health decisions with a qualified clinician.

Combinations & interactions

9 entries

Check cautions and reported pairings. A compatibility claim does not establish that a combination is safe.

PT-141

Caution reported

Overlapping receptor/BP effects.15

Reference report · Pep-Pedia label: Use Caution

Alpha-MSH

Avoidance reported

Overlapping receptor stimulation.15

Reference report · Pep-Pedia label: Avoid Combination

Cialis/Viagra

Caution reported

Priapism/cardiovascular concern.15

Reference report · Pep-Pedia label: Monitor Combination

Blood-pressure medicines

Caution reported

Unpredictable pressure effects.15

Reference report · Evidence context: Monitor combination

Appetite suppressants

Caution reported

Excess intake reduction.15

Reference report · Pep-Pedia label: Monitor Combination

BPC-157

Unverified pairing

Safety unestablished.15

Reference report · Pep-Pedia label: Compatible

Growth-hormone peptides

Unverified pairing

Safety unestablished.15

Reference report · Pep-Pedia label: Compatible

Thyroid medicines

Unverified pairing

No direct evidence cited.15

Reference report · Evidence context: Unknown

Other melanocortin peptides, including PT-141

Not established

Combination safety was not established in the cited single-compound pilot. Similar reported effects do not validate stacking.1

Research context

Reconstitution calculator

Enter your peptide amount and container size. Get a volume and a simple measurement scale.

mg

Total labeled amount of Melanotan II.

mL

Usable capacity of the destination vial or pen cartridge.

1 dial unit = 0.01 mL on the documented V2 model. Confirm your pen’s scale.

Vial examples & blend contents Melanotan II

Listed amounts are packaging examples. Check your actual label.

Reconstitution

No validated human preparation verified

No formulation-specific human reconstitution instructions were verified for this research powder.1

Diluent and storage

A compatible solvent, concentration, preservative and beyond-use period cannot be inferred from vial mass. The cited source does not validate a universal bacteriostatic-water recipe.1

Reference preparation details

Reported handling information, not a validated formulation or instruction to prepare an injectable product.

Injectable

Pep-Pedia describes preparation for this route; product-specific stability has not been independently verified.

Solvents mentioned
Bacteriostatic water
Reported parameters
Source temperature: 2-8°C. · Reported post-preparation interval: 30 days. · The source specifies protection from light.

The source describes gentle mixing and avoiding vigorous shaking.

Topical

The topical steps describe a propylene-glycol vehicle and penetration-enhancing cream base.

Solvents mentioned
Propylene glycol
Reported parameters
Reported topical pH: 5.5–6.5. · The source describes an airless container and protection from light.

The generic BAC-water banner is not treated as topical formulation guidance.

Nasal

Pep-Pedia reports a nasal concentration and assumed pump volume.

Solvents mentioned
Bacteriostatic water
Reported parameters
10 mg/mL at 0.1 mL per spray gives 1 mg per spray. · The pump volume must be calibrated; 0.1 mL is not universal. · Reported storage: refrigerated and light-protected; the page banner gives 30 days.
15
Appearance & documentation

Appearance and a purity certificate cannot establish sterility, identity, or suitability for injection.

Reported appearanceWhite to off-white lyophilized powderReported appearanceClear to pale yellow when reconstitutedReported variationProtect from light exposureReported concernBrown or dark colored powderReported concernCloudy solution after mixingReported appearanceVacuum sealed vial
15

Vial sizes

10mg7

Packaging examples, not a market survey. Approved and research products are not interchangeable.

Storage after mixing

Reconstituted research vials

Refrigerated lifetime not established

The checked sources do not establish how long this research preparation remains stable and sterile after mixing.15

Full storage notes from Pep-Pedia15
Injectable

Refrigerate reconstituted peptide, protect from light

Topical

Refrigerate cream, use within 30 days

Nasal

Refrigerate spray bottle, keep upright

Storage depends on the formulation, diluent, container, and handling. Follow the specific product label or pharmacist’s instructions.

Pen & syringe measurements Scales, capacity & references

Pen & syringe measurements

Device units measure volume. Concentration determines the amount in mg.

Open calculator ↗
V2 peptide pen

1 notch = 0.01 mL

Documented 1-unit V2 models

One dial increment
1 unit
Cartridge capacity
3 mL
Maximum setting
60 units · 0.60 mL

Use the numbered dose window. Whole-unit settings only; confirm the specification for your exact model.

U-100 syringe

1 unit = 0.01 mL

100 units = 1 mL

10 units
0.10 mL
30-unit capacity
0.30 mL
50 / 100-unit capacity
0.50 / 1 mL

Read the printed unit scale. A small line may represent 0.5, 1, or 2 units depending on the syringe.

Other measuring tools

Use the mL scale

mL syringes and calibrated pipettes

0.01 mL
10 µL
0.10 mL
100 µL
Amount
mL × mg/mL

Drops, sprays and other pen clicks need their own verified volume per increment. They have no universal conversion.

3 mL is cartridge capacity. It does not mean you must prepare or load 3 mL. The original vial and the pen cartridge are different containers. This reference compares measurement scales; it does not establish product or route compatibility.

Device referencesAVERON V2 specifications ↗SilverLeaf V2 unit reference ↗FDA: syringe unit conversions ↗Specifications checked October 12, 2026.

Research findings

Limited human data

Source context

Source compatibility/photoprotection claims do not establish safety; tanning does not remove UV risk.

Compound identity & other names

A melanocortin agonist studied for pigmentation and erectile responses. Early human findings are small and short term, while serious adverse events have been reported; it is not an established tanning medicine.

Other names: Melanotan 2 · MT-2 · MT-II · MT2

No FDA-approved Melanotan II product. Afamelanotide/Scenesse approval does not apply to Melanotan II.

How it may work

MC1 pigmentation and broader melanocortin appetite/arousal signaling; route-specific exposure remains uncertain.15

Pigmentation signal in only three volunteers

A 1996 phase I pilot found increased pigmentation in two of three men. Nausea occurred at most tested doses; the highest dose caused moderate sleepiness and fatigue in one of two recipients.

1

Safety uncertainty is substantial

FDA cites reports of melanoma, priapism, and serious neurologic/toxic reactions. Case reports flag possible harm without establishing frequency or proving causation.

2

New report of persistent oral pigmentation

A 2026 case describes gum and cheek pigmentation during self-injection. Gum pigmentation was still visible three months after stopping. The report cannot establish how frequently this occurs.

5
Research areas and evidence gaps

Sexual effects. Spontaneous erections were observed in the pilot; this is not an approved treatment indication.1

  • Long-term risk, reliable product quality, and benefit-risk balance for tanning.
  • Whether any skin-color change provides meaningful protection; tanning is not evidence that UV exposure is safe.
Community reports Unvalidated

PepPedia describes tanning, appetite, and libido use; the claimed benefits are broader than the pilot evidence.6

PepPedia's editorial protocol summary, not measured community consensus. Benefits, product identity, and safety are not independently verified; these reported practices are not recommendations.

Search coverage and review status

Added a 2026 case of persistent oral pigmentation; a case report cannot estimate incidence or causation.

Checked
2026-10-12
Search
"melanotan" 2025 2026
Catalog
Pep-Pedia ↗ · 6 listed references retained
  • Targeted search and selected primary-source checks, not an exhaustive systematic review.
  • Preserved bibliography entries marked unreviewed have not had their findings independently verified.

AI-prepared summaries. Independent medical editorial review is pending.

References

Original sources and review status. Open a reference to read its summary.

15 sources

1Melanotan-II: pilot phase I studyTrial · 1996 · pubmed.ncbi.nlm.nih.govAbstract checked
AI-PREPARED SUMMARY

A three-man pilot observed pigmentation and erectile effects, alongside nausea and dose-limiting fatigue; it cannot establish chronic tanning safety.

Pigmentation signal in only three volunteers

A 1996 phase I pilot found increased pigmentation in two of three men. Nausea occurred at most tested doses; the highest dose caused moderate sleepiness and fatigue in one of two recipients.

Original source
2FDA: compounding safety concernsRegulator · 2026 · fda.govPrimary source checked
AI-PREPARED SUMMARY

Regulatory safety assessment.

Safety uncertainty is substantial

FDA cites reports of melanoma, priapism, and serious neurologic/toxic reactions. Case reports flag possible harm without establishing frequency or proving causation.

Original source
3FDA notice concerning unapproved Melanotan IIRegulator · 2016 · fda.govPrimary source checked
AI-PREPARED SUMMARY

FDA describes Melanotan II as an unapproved new drug.

Original source
4PubChem: Melanotan II, CID 92432Registry · 2026 · pubchem.ncbi.nlm.nih.govPrimary source checked
AI-PREPARED SUMMARY

Chemical identity record: cyclic seven-residue peptide, C50H69N15O9, average molecular weight 1024.2 g/mol.

Original source
5Changes in Oral Mucosa Associated with Melanotan II Injections: A Case ReportReference · 2026 · pubmed.ncbi.nlm.nih.govAbstract checked
AI-PREPARED SUMMARY

One patient developed gingival and cheek pigmentation after 64 days of self-administered injections. Cheek pigmentation nearly cleared after stopping; gingival discoloration persisted at three months. A case cannot estimate incidence.

New report of persistent oral pigmentation

A 2026 case describes gum and cheek pigmentation during self-injection. Gum pigmentation was still visible three months after stopping. The report cannot establish how frequently this occurs.

Additional research · Checked 2026-10-12

Original source
6PepPedia: reported practices (accessed October 12, 2026)Community · 2026 · pep-pedia.orgCommunity source checked
AI-PREPARED SUMMARY

Secondary editorial account of discussed practices; not a clinical trial or representative survey.

Original source
7Research catalog: labeled quantitiesCatalog · 2026 · apexlab.orgCatalog checked
AI-PREPARED SUMMARY

Lists a 10 mg lyophilized vial. Quantity examples only; vendor quality and suitability are not endorsed.

Original source
8Cardiovascular Effects Assessment (2018)No study link suppliedReference · Accessed 2026 · pep-pedia.orgPep-Pedia report · Primary source not checked
AI-PREPARED SUMMARY

Pep-Pedia reports: Transient pulse and blood-pressure increases are claimed in monitored humans, but the card provides no original study link or event rates.

Reported population / model
Human

Reported study details
Various doses · Acute monitoring · Mild BP elevation

Pep-Pedia supplies no original study link for this card. Study identity, design, doses and result remain unverified. No study link supplied

Read the Pep-Pedia report ↗

Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12

Source report
9Photoprotection in Fair-Skinned Individuals (2015)No study link suppliedReference · Accessed 2026 · pep-pedia.orgPep-Pedia report · Primary source not checked
AI-PREPARED SUMMARY

Pep-Pedia reports: The source claims less UV erythema in fair-skinned people; no study link is supplied and tanning does not establish melanoma protection.

Reported population / model
Human (Fitzpatrick Type I-II)

Reported study details
0.1mg/kg · 3 months · Reduced sunburn incidence

Pep-Pedia supplies no original study link for this card. Study identity, design, doses and result remain unverified. No study link supplied

Read the Pep-Pedia report ↗

Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12

Source report
10Female Sexual Arousal Disorder Trial (2004)No study link suppliedReference · Accessed 2026 · pep-pedia.orgPep-Pedia report · Primary source not checked
AI-PREPARED SUMMARY

Pep-Pedia reports: The source attributes a female-arousal trial to Melanotan II; compound attribution needs verification because related melanocortins have separate trials.

Reported population / model
Human (Female)

Reported study details
0.025mg/kg · Single dose · 73% reported arousal

Pep-Pedia supplies no original study link for this card. Study identity, design, doses and result remain unverified. No study link supplied

Read the Pep-Pedia report ↗

Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12

Source report
11Appetite and Food Intake Study (2001)No study link suppliedReference · Accessed 2026 · pep-pedia.orgPep-Pedia report · Primary source not checked
AI-PREPARED SUMMARY

Pep-Pedia reports: A 15% food-intake reduction and modest weight loss are claimed; the original human trial is not linked.

Reported population / model
Human

Reported study details
1mg daily · 6 weeks · 15% reduction in caloric intake

Pep-Pedia supplies no original study link for this card. Study identity, design, doses and result remain unverified. No study link supplied

Read the Pep-Pedia report ↗

Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12

Source report
12Phase II Trial of Melanotan II in Erectile Dysfunction (2000)No study link suppliedReference · Accessed 2026 · pep-pedia.orgPep-Pedia report · Primary source not checked
AI-PREPARED SUMMARY

Pep-Pedia reports: The source reports an 80% erectile response in men and onset within one to two hours; study duration and compound attribution need verification.

Reported population / model
Human

Reported study details
0.025mg/kg · 3 months · 80% response rate

Pep-Pedia supplies no original study link for this card. Study identity, design, doses and result remain unverified. No study link supplied

Read the Pep-Pedia report ↗

Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12

Source report
13Melanogenesis and UV Protection Study (1999)No study link suppliedReference · Accessed 2026 · pep-pedia.orgPep-Pedia report · Primary source not checked
AI-PREPARED SUMMARY

Pep-Pedia reports: Greater pigmentation and UV-response measures are claimed; the dose/formulation may overlap Melanotan I research and needs confirmation.

Reported population / model
Human

Reported study details
0.16mg/kg daily · 10 days · Increased melanin density

Pep-Pedia supplies no original study link for this card. Study identity, design, doses and result remain unverified. No study link supplied

Read the Pep-Pedia report ↗

Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12

Source report
14Pep-Pedia: Melanotan II — reported pharmacokineticsReference estimate; not independently verified human PKCommunity · 2026 · pep-pedia.orgCommunity source checked
AI-PREPARED SUMMARY

Lists a half-life of 1 hr and a peak time of 30 min. Stated attribution: Dorr et al. 1996 J Natl Cancer Inst 88(17):1196-1201 (MT-I human subQ PK; class inference applied to MT-II). The source identifies this as a class-level inference, not a measured half-life for this compound. Pep-Pedia identifies this as a class inference from human melanotan-I data. It is not a measured melanotan-II half-life. Five half-lives is not complete clearance, and the source’s “cleared” value is not used as a measured endpoint.

Secondary reference page checked; the underlying quantitative claim is not independently confirmed. · Checked 2026-10-12

Original source
15Pep-Pedia: Melanotan II — route-specific referenceReference page checked; underlying claims require separate verification.Community · Checked 2026 · pep-pedia.orgCommunity source checked
AI-PREPARED SUMMARY

Source page checked across available routes. Protocols, cycles, storage, mechanisms and pairing claims are secondary reports; checking the page does not independently validate those claims. Original concise summaries are used here.

Content coverage audit · Checked 2026-10-12

Original source
Source details