Weight-management research
2Selective amylin pathway agonism in adults.
Selective long-acting amylin receptor agonist (LY3841136)
Investigational; no FDA-approved eloralintide formulation.
Investigational AMY1-selective amylin agonist developed for obesity; human trial evidence is substantially stronger than community-only peptides.
Selective amylin pathway agonism in adults.
Source reports 9.5–20.1% mean weight reduction at 48 weeks versus 0.4% placebo; body-composition claims include preclinical findings.
Reported waist, glucose, lipid, inflammation and blood-pressure improvements; clinical event prevention unproven.
Reasons people report using it; these do not establish benefit.16
Research-market product identity, purity and formulation cannot be established from a publication.2
4 distinct primary sources or abstracts checked. Evidence may concern a parent compound, individual blend ingredient, animal, or cell model; it does not necessarily establish a benefit for this exact product.
Evidence definitions →The checked material does not establish a human adverse-event rate or safe self-use regimen for this exact product.4
Investigational; no FDA-approved eloralintide formulation.
An exact sequence has not been verified for this formulation.
Reference identity · not independently confirmed16
Selective long-acting amylin receptor agonist (LY3841136)
Salt, hydration, glycosylation and blend composition may change the supplied material; no unsupported formula or mass is assigned.
37 amino acids · Lipidated 37-amino-acid analog (exact MW not publicly disclosed by Lilly)
Modified human amylin scaffold with 3 non-coded amino acid residues at positions 11, 15, and 22; C-terminally amidated linear polypeptide (L-configuration only). Full sequence disclosed in US Patent 2022/0288168 A1.Reference description; checked chemical identity above takes precedence when available.16
This value is reported by a secondary reference. The stated attribution has not been independently verified as a route- and formulation-matched human PK measurement.
Illustrative scenario using an unverified reference estimate. Shading shows the reported half-life range. No midpoint is assumed.
Five half-lives in this estimated model. This is not a prediction of when effects stop.
Population: Not established by the reference estimate
Source’s stated attribution: Briere et al. Mol Metab 2025 (PMID 41109426)
Source’s reported peak time: 4.2 days. This has not been independently confirmed and is not used in the elimination curve.
100 × 2−time / half-life. Time zero is a reference level, not the moment of administration. Absorption, repeated dosing, metabolites and clinical effects are not modeled. Five half-lives leaves 3.125%, not zero. This curve cannot determine a dosing interval.
At 48 weeks, efficacy-estimand changes ranged from approximately −9% to −20% across regimens, compared with −0.4% for placebo. These estimates assume the trial’s analysis conditions.2
A 2026 publication describes 100 participants in multiple-ascending-dose cohorts. It complements, rather than replaces, the larger phase 2 evidence.3
Voluntary, unverified reports. These percentages do not measure effectiveness or safety.
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The source displays “308 responses” for this profile. This is not a confirmed participant count or a denominator for individual questions.
Compare purpose, amount, route, frequency, and duration.
Interaction categories describe reference claims; investigational combinations require trial-level evidence.
Scroll to compare all columns →
| Route | Dose | Frequency | Goal / evidence | Duration | References |
|---|---|---|---|---|---|
| SubQSubcutaneous | 1 mg — separate escalation cohort | Once weekly | Phase 2 obesity trialHuman study | 48 weeks | 2 |
Population 263 adults without type 2 diabetes Context Studied under protocol supervision; this is not a self-administration recommendation. Source dose wording 1, 3, 6 or 9 mg; separate escalation cohorts | |||||
| SubQSubcutaneous | 3 mg — separate escalation cohort | Once weekly | Phase 2 obesity trialHuman study | 48 weeks | 2 |
Population 263 adults without type 2 diabetes Context Studied under protocol supervision; this is not a self-administration recommendation. Source dose wording 1, 3, 6 or 9 mg; separate escalation cohorts | |||||
| SubQSubcutaneous | 6 mg — separate escalation cohort | Once weekly | Phase 2 obesity trialHuman study | 48 weeks | 2 |
Population 263 adults without type 2 diabetes Context Studied under protocol supervision; this is not a self-administration recommendation. Source dose wording 1, 3, 6 or 9 mg; separate escalation cohorts | |||||
| SubQSubcutaneous | 9 mg — separate escalation cohort | Once weekly | Phase 2 obesity trialHuman study | 48 weeks | 2 |
Population 263 adults without type 2 diabetes Context Studied under protocol supervision; this is not a self-administration recommendation. Source dose wording 1, 3, 6 or 9 mg; separate escalation cohorts | |||||
| SubQ | 1 mg weekly | Once weekly | Phase 2 Low Dose (Monotherapy)Reference report | Continuous treatment under investigation; long-term durability data not yet available | 16 |
Population Population not independently verified; see the reference and linked research. Context Reported in Pep-Pedia’s educational protocol table. Study attribution and applicability to this exact product are not independently established. Interaction categories describe reference claims; investigational combinations require trial-level evidence. Source tabs Injectable | |||||
| SubQ | 3 mg weekly | Once weekly | Phase 2 Mid DoseReference report | Continuous treatment under investigation; long-term durability data not yet available | 16 |
Population Population not independently verified; see the reference and linked research. Context Reported in Pep-Pedia’s educational protocol table. Study attribution and applicability to this exact product are not independently established. Interaction categories describe reference claims; investigational combinations require trial-level evidence. Source tabs Injectable | |||||
| SubQ | 6 mg weekly | Once weekly | Phase 2 High DoseReference report | Continuous treatment under investigation; long-term durability data not yet available | 16 |
Population Population not independently verified; see the reference and linked research. Context Reported in Pep-Pedia’s educational protocol table. Study attribution and applicability to this exact product are not independently established. Interaction categories describe reference claims; investigational combinations require trial-level evidence. Source tabs Injectable | |||||
| SubQ | 9 mg weekly | Once weekly | Phase 2 Maximum DoseReference report | Continuous treatment under investigation; long-term durability data not yet available | 16 |
Population Population not independently verified; see the reference and linked research. Context Reported in Pep-Pedia’s educational protocol table. Study attribution and applicability to this exact product are not independently established. Interaction categories describe reference claims; investigational combinations require trial-level evidence. Source tabs Injectable | |||||
| SubQ | 3 mg → 9 mg over multiple weeks | Once weekly with stepwise escalation | Slow Dose Escalation (improves tolerability)Reference report | Continuous treatment under investigation; long-term durability data not yet available | 16 |
Population Population not independently verified; see the reference and linked research. Context Reported in Pep-Pedia’s educational protocol table. Study attribution and applicability to this exact product are not independently established. Interaction categories describe reference claims; investigational combinations require trial-level evidence. Source tabs Injectable | |||||
| SubQSubQ (separate injections) | Eloralintide + tirzepatide (doses under study) | Once weekly each | Combination with Tirzepatide (ATTAIN — Investigational)Reference report | Continuous treatment under investigation; long-term durability data not yet available | 16 |
Population Population not independently verified; see the reference and linked research. Context Reported in Pep-Pedia’s educational protocol table. Study attribution and applicability to this exact product are not independently established. Interaction categories describe reference claims; investigational combinations require trial-level evidence. Source tabs Injectable | |||||
No protocols match these filters.
Study and label doses retain their study context. Reference reports are unvalidated practices, not personal treatment instructions. Ranges remain ranges; escalation stages are labeled.
Reported use periods and breaks. These do not establish a safe cycle or prove that breaks prevent tolerance.
Same day each week, with or without food
The checked material does not establish a human adverse-event rate or safe self-use regimen for this exact product.
4Dose/escalation-related nausea and fatigue; dehydration risk.
Persistent vomiting/diarrhea, severe abdominal/back pain, allergy, abscess, fainting, tachycardia or hypoglycemia.
Pregnancy, lactation, children and many chronic diseases lack established safety.
Not a complete safety screen. Discuss health decisions with a qualified clinician.
Check cautions and reported pairings. A compatibility claim does not establish that a combination is safe.
Overlapping amylin action.16
Reference report · Pep-Pedia label: Avoid CombinationOverlapping amylin action.16
Reference report · Pep-Pedia label: Avoid CombinationNo direct evidence cited; additive GI effects.16
Reference report · Pep-Pedia label: Monitor CombinationUntested; additive GI burden.16
Reference report · Pep-Pedia label: Use CautionHypoglycemia and meal-absorption concerns.16
Reference report · Pep-Pedia label: Monitor CombinationPossible absorption change; precise timing unestablished.16
Reference report · Pep-Pedia label: Requires TimingCombination under investigation.16
Reference report · Pep-Pedia label: SynergisticClass extrapolation.16
Reference report · Pep-Pedia label: CompatibleClass extrapolation.16
Reference report · Pep-Pedia label: CompatibleNo clinical interaction study for the exact proposed combination was verified; absence of evidence does not establish compatibility.4
Research contextNo matching interactions. Try another name or filter.
No universal bacteriostatic-water volume or validated preparation method is established for this entry.4
Reported handling information, not a validated formulation or instruction to prepare an injectable product.
Pep-Pedia identifies sponsor-controlled trial presentations and no validated consumer-powder reconstitution protocol.
Clinical-trial handling instructions do not validate independently sourced research powder.
Appearance and a purity certificate cannot establish sterility, identity, or suitability for injection.
No verified packaging examples included.
Packaging examples, not a market survey. Approved and research products are not interchangeable.
The checked sources do not establish how long this research preparation remains stable and sterile after mixing.16
Storage depends on the formulation, diluent, container, and handling. Follow the specific product label or pharmacist’s instructions.
Interaction categories describe reference claims; investigational combinations require trial-level evidence.
An investigational amylin receptor agonist with phase 1 and phase 2 human obesity studies. A weekly research regimen is not an approved product instruction.
Investigational; no FDA-approved eloralintide formulation.
Promotes satiety through amylin receptors; delayed gastric emptying may affect oral medicines. Receptor selectivity does not establish superiority to untested comparators.16
At 48 weeks, efficacy-estimand changes ranged from approximately −9% to −20% across regimens, compared with −0.4% for placebo. These estimates assume the trial’s analysis conditions.
2A 2026 publication describes 100 participants in multiple-ascending-dose cohorts. It complements, rather than replaces, the larger phase 2 evidence.
3263 adults without type 2 diabetes were randomized. Mean weight change ranged about −9% to −20% across active regimens versus −0.4% placebo; GI adverse effects varied with dose/escalation. This establishes monotherapy trial efficacy, not research-vial equivalence.
Human randomized phase 2 trial; peer-reviewed Lancet report17Sponsor reported 367 adults with obesity/overweight and type 2 diabetes: highest combination arm lost23.3% versus14.8% with tirzepatide15 mg; A1C fell2.9 versus2.4 percentage points. Adverse-event discontinuations were10.8–27.0% across combination arms versus2.9% with tirzepatide. These are sponsor-announced results, not a checked peer-reviewed publication.
Sponsor announcement of randomized phase 2b results18Weight-management research. Selective amylin pathway agonism in adults.2
Weight discussions as described by Pep-Pedia.4
No representative survey, independently verified products, or controlled outcomes.
The targeted check identified relevant additional literature or current regulatory information; checked findings are separated from retained bibliography-only references.
AI-prepared summaries. Independent medical editorial review is pending.
Original sources and review status. Open a reference to read its summary.
263 participants; efficacy-estimand mean weight change reached approximately −20% in selected 9 mg regimens versus −0.4% with placebo.
Pep-Pedia bibliography · Checked 2026-10-12
263 participants; efficacy-estimand mean weight change reached approximately −20% in selected 9 mg regimens versus −0.4% with placebo.
At 48 weeks, efficacy-estimand changes ranged from approximately −9% to −20% across regimens, compared with −0.4% for placebo. These estimates assume the trial’s analysis conditions.
Additional research · Checked 2026-10-12
2026 report of a randomized multiple-ascending-dose program in 100 participants; adds early development evidence, not long-term outcomes.
A 2026 publication describes 100 participants in multiple-ascending-dose cohorts. It complements, rather than replaces, the larger phase 2 evidence.
Additional research · Checked 2026-10-12
Accessed October 12, 2026. Secondary descriptions and bibliography; community schedules are unvalidated reports, not recommendations.
Pep-Pedia reports: Day-29 weight changes were −2.5% at 4 mg and −4.4% at 12 mg; the reported half-life was 310–366 hours.
Reported population / model
Humans (N=48, healthy adults)
Reported study details
Single SC dose 0.04–12 mg · 29-day observation · −2.5% (4 mg) and −4.4% (12 mg) body weight at day 29
Reported by Pep-Pedia; the linked publication, design, doses and result have not been independently verified here.
Read the Pep-Pedia report ↗Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12
Pep-Pedia reports: Obese rats lost up to 12.3% weight; the source attributes 85% to fat and reports less lean loss and taste aversion than cagrilintide.
Reported population / model
DIO rats
Reported study details
0.1–100 nmol/kg every 3 days · Weight loss up to −12.3% at day 13
Reported by Pep-Pedia; the linked publication, design, doses and result have not been independently verified here.
Read the Pep-Pedia report ↗Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12
Pep-Pedia reports: This is a registered comparison of eloralintide alone and with tirzepatide; the card supplies planned endpoints rather than results.
Reported population / model
Humans, T2D + obesity
Reported study details
Eloralintide ± tirzepatide · 48-week primary endpoint
Reported by Pep-Pedia; the linked publication, design, doses and result have not been independently verified here.
Read the Pep-Pedia report ↗Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12
Pep-Pedia reports: The card lists additional weekly monotherapy programs and development plans; it provides no completed efficacy results for those registrations.
Reported population / model
Humans with obesity
Reported study details
Once-weekly SC · Multi-dose, dose-escalation designs
Reported by Pep-Pedia; the linked publication, design, doses and result have not been independently verified here.
Read the Pep-Pedia report ↗Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12
Pep-Pedia reports: Cell assays reported hAMY1R EC50 of 23.9 pM versus 291 pM at CTR and 254 pM at AMY3R; clinical tolerability cannot be inferred directly.
Reported population / model
In vitro human and rat receptor cells
Reported study details
cAMP and ligand binding · EC50 = 23.9 pM (hAMY1R)
Reported by Pep-Pedia; the linked publication, design, doses and result have not been independently verified here.
Read the Pep-Pedia report ↗Pep-Pedia reference card; original summary of its reported findings · Checked 2026-10-12
Listed in Pep-Pedia’s bibliography; the linked publication and its findings have not been independently verified in this pass.
Pep-Pedia bibliography · Checked 2026-10-12
Listed in Pep-Pedia’s bibliography; the linked publication and its findings have not been independently verified in this pass.
Pep-Pedia bibliography · Checked 2026-10-12
Listed in Pep-Pedia’s bibliography; the linked publication and its findings have not been independently verified in this pass.
Pep-Pedia bibliography · Checked 2026-10-12
Listed in Pep-Pedia’s bibliography; the linked publication and its findings have not been independently verified in this pass.
Pep-Pedia bibliography · Checked 2026-10-12
Listed in Pep-Pedia’s bibliography; the linked publication and its findings have not been independently verified in this pass.
Pep-Pedia bibliography · Checked 2026-10-12
Lists a half-life of 12.9 days – 15.3 days and a peak time of 4.2 days. Stated attribution: Briere et al. Mol Metab 2025 (PMID 41109426). This value is reported by a secondary reference. The stated attribution has not been independently verified as a route- and formulation-matched human PK measurement. Five half-lives is not complete clearance, and the source’s “cleared” value is not used as a measured endpoint.
Secondary reference page checked; the underlying quantitative claim is not independently confirmed. · Checked 2026-10-12
Source page checked across available routes. Protocols, cycles, storage, mechanisms and pairing claims are secondary reports; checking the page does not independently validate those claims. Original concise summaries are used here.
Content coverage audit · Checked 2026-10-12
263 adults without type 2 diabetes were randomized. Mean weight change ranged about −9% to −20% across active regimens versus −0.4% placebo; GI adverse effects varied with dose/escalation. This establishes monotherapy trial efficacy, not research-vial equivalence.
263 adults without type 2 diabetes were randomized. Mean weight change ranged about −9% to −20% across active regimens versus −0.4% placebo; GI adverse effects varied with dose/escalation. This establishes monotherapy trial efficacy, not research-vial equivalence.
Additional primary-source check · Checked 2026-10-12
Sponsor reported 367 adults with obesity/overweight and type 2 diabetes: highest combination arm lost23.3% versus14.8% with tirzepatide15 mg; A1C fell2.9 versus2.4 percentage points. Adverse-event discontinuations were10.8–27.0% across combination arms versus2.9% with tirzepatide. These are sponsor-announced results, not a checked peer-reviewed publication.
Sponsor reported 367 adults with obesity/overweight and type 2 diabetes: highest combination arm lost23.3% versus14.8% with tirzepatide15 mg; A1C fell2.9 versus2.4 percentage points. Adverse-event discontinuations were10.8–27.0% across combination arms versus2.9% with tirzepatide. These are sponsor-announced results, not a checked peer-reviewed publication.
Additional primary-source check · Checked 2026-10-12