.mix-calculator[data-astro-cid-nml5rtwh]{color:#304b6c;max-width:790px;margin:0}.mix-modes[data-astro-cid-nml5rtwh]{border-bottom:1px solid #e0e7ef;gap:6px;margin-bottom:28px;padding-bottom:16px;display:flex}.mix-modes[data-astro-cid-nml5rtwh] button[data-astro-cid-nml5rtwh]{font:inherit;color:#647b96;border:1px solid #0000;border-radius:7px;padding:12px 16px;font-size:13px}.mix-modes[data-astro-cid-nml5rtwh] button[data-astro-cid-nml5rtwh][aria-pressed=true]{color:#265fa9;background:#edf4ff;border-color:#c7daf3;font-weight:600}.mix-step[data-astro-cid-nml5rtwh]{margin:0 0 27px}.mix-step[data-astro-cid-nml5rtwh]>label[data-astro-cid-nml5rtwh]{color:#273e5a;align-items:center;gap:11px;margin-bottom:14px;font-size:17px;font-weight:600;line-height:1.5;display:flex}.mix-step-number[data-astro-cid-nml5rtwh]{color:#456e9f;background:#eef3fa;border-radius:50%;flex-shrink:0;place-items:center;width:27px;height:27px;font-size:12px;display:inline-grid}.mix-input[data-astro-cid-nml5rtwh]{background:#fff;border:1px solid #cbd8e8;border-radius:8px;align-items:center;max-width:360px;display:flex;overflow:hidden}.mix-input[data-astro-cid-nml5rtwh] input[data-astro-cid-nml5rtwh]{color:#264b7a;background:0 0;border:0;width:100%;min-width:0;height:54px;padding:13px 15px;font-size:22px}.mix-input[data-astro-cid-nml5rtwh]>span[data-astro-cid-nml5rtwh]{color:#6f849c;padding:0 18px;font-size:14px}.mix-input[data-astro-cid-nml5rtwh]:focus-within{outline-offset:2px;outline:2px solid #87aee3}.mix-help[data-astro-cid-nml5rtwh]{color:#6f8197;margin-top:9px;font-size:12px;line-height:1.8}.mix-label[data-astro-cid-nml5rtwh]{margin-top:18px;font-size:13px;font-weight:550;line-height:1.7;display:block}.mix-label[data-astro-cid-nml5rtwh]>select[data-astro-cid-nml5rtwh],.mix-label[data-astro-cid-nml5rtwh]>input[data-astro-cid-nml5rtwh],.mix-label[data-astro-cid-nml5rtwh]>input{font:inherit;color:#365473;background:#fff;border:1px solid #cbd8e8;border-radius:8px;width:100%;min-height:47px;margin-top:7px;padding:12px;font-size:15px;display:block}.mix-label[data-astro-cid-nml5rtwh] .mix-input[data-astro-cid-nml5rtwh]{margin-top:9px}.mix-input[data-astro-cid-nml5rtwh]>select[data-astro-cid-nml5rtwh]{color:#476786;background:#f5f8fc;border:0;border-left:1px solid #dce5ef;align-self:stretch;padding:0 14px;font-size:13px}.mix-reference[data-astro-cid-nml5rtwh]{border-top:1px solid #e3eaf2;border-bottom:1px solid #e3eaf2;margin-top:24px;padding:19px 0}.mix-reference[data-astro-cid-nml5rtwh] summary[data-astro-cid-nml5rtwh]{cursor:pointer;color:#526f91;font-size:13px;line-height:1.7}.mix-reference[data-astro-cid-nml5rtwh] summary[data-astro-cid-nml5rtwh]>span[data-astro-cid-nml5rtwh]{color:#8897a9;margin-left:10px;font-size:11px}.mix-presets[data-astro-cid-nml5rtwh]{flex-wrap:wrap;gap:8px;margin-top:15px;display:flex}.mix-presets[data-astro-cid-nml5rtwh] button{color:#416590;background:#f9fbff;border:1px solid #d4e0ef;border-radius:6px;padding:9px 12px;font-size:12px}.mix-actions[data-astro-cid-nml5rtwh]{flex-wrap:wrap;align-items:center;gap:16px;margin-top:24px;display:flex}.mix-actions[data-astro-cid-nml5rtwh] .text-button[data-astro-cid-nml5rtwh]{color:#58759b;font-size:12px}.mix-error[data-astro-cid-nml5rtwh]{color:#995846;background:#fff7f4;border:1px solid #eccdc5;border-radius:8px;margin-top:24px;padding:15px 18px;font-size:13px;line-height:1.8}.mix-result[data-astro-cid-nml5rtwh]{background:#f7faff;border:1px solid #c9dcf7;border-radius:12px;margin-top:32px;padding:30px;scroll-margin-top:85px}.mix-result-header[data-astro-cid-nml5rtwh]>span[data-astro-cid-nml5rtwh]{color:#4b6f9c;font-size:13px}.mix-result-header[data-astro-cid-nml5rtwh]>strong[data-astro-cid-nml5rtwh]{letter-spacing:-1.5px;color:#245fa9;margin-top:7px;font-size:52px;font-weight:750;line-height:1.35;display:block}.mix-result-header[data-astro-cid-nml5rtwh] small[data-astro-cid-nml5rtwh]{letter-spacing:-.3px;font-size:23px;font-weight:500}.mix-result-header[data-astro-cid-nml5rtwh] p[data-astro-cid-nml5rtwh]{color:#617b9b;margin-top:6px;font-size:12px;line-height:1.8}.mix-water[data-astro-cid-nml5rtwh]{border-top:1px solid #dce6f4;flex-wrap:wrap;justify-content:space-between;gap:10px 20px;margin-top:22px;padding-top:20px;font-size:13px;display:flex}.mix-water[data-astro-cid-nml5rtwh] strong[data-astro-cid-nml5rtwh]{color:#345d8e;white-space:nowrap}.mix-water[data-astro-cid-nml5rtwh] p[data-astro-cid-nml5rtwh]{color:#7d715b;width:100%;margin:4px 0 0;font-size:12px;line-height:1.8}.mix-scale-summary[data-astro-cid-nml5rtwh]{background:#fff;border:1px solid #d9e5f5;border-radius:9px;flex-wrap:wrap;align-items:baseline;gap:8px 14px;margin-top:24px;padding:20px;display:flex}.mix-scale-summary[data-astro-cid-nml5rtwh]>span[data-astro-cid-nml5rtwh]{color:#4c688a;font-size:14px}.mix-scale-summary[data-astro-cid-nml5rtwh] strong[data-astro-cid-nml5rtwh]{color:#265c9b;font-size:26px;font-weight:700}.mix-scale-summary[data-astro-cid-nml5rtwh] small[data-astro-cid-nml5rtwh]{color:#7a8da6;width:100%;margin-top:3px;font-size:11px;display:block}.mix-scale[data-astro-cid-nml5rtwh]{border-collapse:collapse;text-align:left;width:100%;margin-top:25px}.mix-scale[data-astro-cid-nml5rtwh] caption[data-astro-cid-nml5rtwh]{text-align:left;color:#3c5c82;padding-bottom:14px;font-size:14px;font-weight:600}.mix-scale[data-astro-cid-nml5rtwh] caption[data-astro-cid-nml5rtwh] span[data-astro-cid-nml5rtwh]{color:#8292a6;margin-top:6px;font-size:11px;font-weight:400;display:block}.mix-scale[data-astro-cid-nml5rtwh] th[data-astro-cid-nml5rtwh]{color:#6d83a0;border-bottom:1px solid #d4e2f2;padding:12px 0;font-size:11px;font-weight:500}.mix-scale[data-astro-cid-nml5rtwh] td{color:#3e638c;border-bottom:1px solid #e0e9f5;padding:15px 0;font-size:15px}.mix-scale[data-astro-cid-nml5rtwh] td:nth-child(2){color:#265b9e;font-weight:700}.mix-scale[data-astro-cid-nml5rtwh] th[data-astro-cid-nml5rtwh]:last-child,.mix-scale[data-astro-cid-nml5rtwh] td:last-child{text-align:right}.mix-more[data-astro-cid-nml5rtwh]{border-top:1px solid #dbe6f5;margin-top:24px;padding-top:20px}.mix-more[data-astro-cid-nml5rtwh] summary[data-astro-cid-nml5rtwh]{color:#4e7099;cursor:pointer;font-size:13px;line-height:1.7}.mix-more[data-astro-cid-nml5rtwh] p[data-astro-cid-nml5rtwh]{color:#6d819d;margin-top:14px;font-size:12px;line-height:1.8}.mix-more[data-astro-cid-nml5rtwh] a[data-astro-cid-nml5rtwh]{color:#356ba9;margin-top:12px;font-size:12px;display:block}.mix-alternatives[data-astro-cid-nml5rtwh]{gap:10px;margin-top:17px;display:grid}.mix-alternatives[data-astro-cid-nml5rtwh] button{text-align:left;color:#40648f;background:#fff;border:1px solid #cedff5;border-radius:7px;padding:13px 15px;font-size:13px}.mix-alternatives[data-astro-cid-nml5rtwh] button[aria-pressed=true]{color:#245b9c;background:#eaf2ff;border-color:#79a0d7}.mix-more[data-astro-cid-nml5rtwh] .mix-conversion[data-astro-cid-nml5rtwh]{color:#2e609f;margin-top:20px;font-size:23px;font-weight:650;line-height:1.6}.mix-more[data-astro-cid-nml5rtwh] .mix-error[data-astro-cid-nml5rtwh]{color:#995846;background:#fff7f4}.mix-blend-note[data-astro-cid-nml5rtwh]{color:#7a684a;margin-top:17px;font-size:12px;line-height:1.8}.mix-blend-scale[data-astro-cid-nml5rtwh]{margin-top:25px}.mix-blend-scale[data-astro-cid-nml5rtwh] h3[data-astro-cid-nml5rtwh]{color:#3c628f;font-size:15px}.mix-blend-scale[data-astro-cid-nml5rtwh] dl>div{color:#527191;justify-content:space-between;gap:18px;margin-top:13px;font-size:12px;display:flex}.mix-blend-scale[data-astro-cid-nml5rtwh] dd{margin:0;font-weight:600}.mix-calculator[data-astro-cid-nml5rtwh] #component-fields input{background:#fff;border:1px solid #cbd8e8;border-radius:7px;width:100%;margin-top:8px;padding:12px;font-size:16px;display:block}.mix-calculator[data-astro-cid-nml5rtwh] [data-astro-cid-nml5rtwh][hidden]{display:none!important}@media (width<=600px){.mix-step[data-astro-cid-nml5rtwh]>label[data-astro-cid-nml5rtwh]{align-items:flex-start;font-size:16px}.mix-input[data-astro-cid-nml5rtwh]{max-width:none}.mix-result[data-astro-cid-nml5rtwh]{margin-inline:-4px;padding:24px 19px}.mix-result-header[data-astro-cid-nml5rtwh]>strong[data-astro-cid-nml5rtwh]{font-size:47px}.mix-scale-summary[data-astro-cid-nml5rtwh]{padding:17px;display:block}.mix-scale-summary[data-astro-cid-nml5rtwh]>strong[data-astro-cid-nml5rtwh]{margin:6px 0;font-size:27px;display:block}.mix-label[data-astro-cid-nml5rtwh]>select[data-astro-cid-nml5rtwh],.mix-calculator[data-astro-cid-nml5rtwh] input{font-size:16px}.mix-modes[data-astro-cid-nml5rtwh]{gap:4px}.mix-modes[data-astro-cid-nml5rtwh] button[data-astro-cid-nml5rtwh]{padding:11px 13px;font-size:12px}.mix-actions[data-astro-cid-nml5rtwh]{gap:12px}.mix-actions[data-astro-cid-nml5rtwh] #load-example[data-astro-cid-nml5rtwh]{text-align:left;width:100%;padding-left:0}.mix-scale[data-astro-cid-nml5rtwh] td{font-size:14px}.mix-reference[data-astro-cid-nml5rtwh] summary[data-astro-cid-nml5rtwh]>span[data-astro-cid-nml5rtwh]{margin-top:4px;margin-left:16px;display:block}}.detail-page{max-width:1200px;padding-bottom:56px}.detail-page .breadcrumb{padding:18px 0;font-size:12px}.detail-header{justify-content:space-between;align-items:center;gap:24px;display:flex}.detail-header h1{letter-spacing:-1.7px;margin-top:12px;font-size:46px;font-weight:750;line-height:1.15}.detail-tagline{color:#5e6d83;margin-top:9px;font-size:15px}.profile-labels{flex-wrap:wrap;align-items:center;gap:7px;display:flex}.purpose-label,.kind-label{border-radius:5px;padding:4px 9px;font-size:11px;font-weight:650;line-height:1.5}.purpose-label{color:#2456a8;background:#eff6ff}.kind-label{color:#595776;background:#f1f2f6}.detail-actions{flex-shrink:0;gap:8px;display:flex}.detail-actions .button{font-size:12px}.profile-description{color:#526071;max-width:890px;margin-top:16px;font-size:15px;line-height:1.75}.profile-meta{color:#5e6d83;align-items:flex-start;gap:20px;margin:10px 0 21px;font-size:12px;display:flex}.profile-meta details{max-width:780px}.profile-meta summary{cursor:pointer;font-weight:500}.profile-meta p{margin-top:10px;font-size:12px}.profile-meta>a{white-space:nowrap;color:#245fc7;margin-left:auto}.quick-facts{grid-template-columns:1.3fr 1fr 1fr 1fr;gap:12px;display:grid}.quick-fact{background:#fff;border:1px solid #e2e8f0;border-radius:10px;flex-direction:column;gap:11px;min-width:0;padding:20px;display:flex}.quick-fact:hover{border-color:#c4d1e3}.fact-label{color:#5e6d83;font-size:12px;font-weight:550}.quick-fact>strong{letter-spacing:-.6px;overflow-wrap:anywhere;color:#172338;font-size:22px;font-weight:700;line-height:1.35}.quick-fact>small{color:#5f6d80;margin-top:auto;font-size:11px}.quick-fact>small>span{color:#2563eb;margin-left:4px}.quick-use strong{letter-spacing:-.15px;font-size:14px;font-weight:600;line-height:1.45;display:block}.quick-use small{color:#66707f;margin-top:3px;font-size:10px;display:block}.section-nav{backdrop-filter:blur(12px);z-index:15;white-space:nowrap;background:#fffffff7;border-bottom:1px solid #e2e8f0;justify-content:flex-start;gap:29px;height:54px;margin:18px 0 22px;display:flex;position:sticky;top:0;overflow-x:auto}.section-nav a{color:#637082;border-bottom:2px solid #0000;height:100%;padding-top:2px;font-size:13px}.section-nav a[aria-current=location]{color:#245fc7;border-bottom-color:#2563eb;font-weight:650}.profile-sections{gap:24px;display:grid}.detail-section{background:#fff;border:1px solid #e1e7ef;border-radius:12px;min-width:0;padding:26px;scroll-margin-top:82px}.detail-section-heading{justify-content:space-between;align-items:center;gap:15px;margin-bottom:17px;display:flex}.detail-section h2,.related-section h2{letter-spacing:-.6px;color:#162339;font-size:23px;font-weight:700}.section-note,.evidence-label{color:#5e6d83;font-size:11px}.evidence-label{color:#3264a8;white-space:nowrap;background:#eff6ff;border-radius:5px;padding:4px 8px}.section-description{color:#5e6d83;margin-bottom:18px;font-size:13px;line-height:1.75}.table-note{color:#677180;margin-top:14px;font-size:11px;line-height:1.7}.table-filters{background:#f3f5f8;border-radius:7px;gap:4px;width:fit-content;margin:18px 0;padding:4px;display:flex}.table-filters button{color:#616f83;border-radius:5px;padding:7px 12px;font-size:12px;font-weight:550}.table-filters button[aria-pressed=true]{color:#245fc7;background:#fff;box-shadow:0 1px 4px #162c4b16}.protocol-scroll{border:1px solid #e2e8f0;border-radius:8px;overflow-x:auto}.protocol-table{border-collapse:collapse;table-layout:fixed;text-align:left;width:100%;min-width:800px}.protocol-table caption{text-align:left}.protocol-table thead{background:#f7f9fc}.protocol-table th,.protocol-table td{vertical-align:top;color:#536175;overflow-wrap:break-word;border-bottom:1px solid #e5eaf0;padding:17px 14px;font-size:12px;font-weight:400;line-height:1.6}.protocol-table thead th{color:#636e7f;padding-block:11px;font-size:11px;font-weight:650}.protocol-table th:first-child{width:23%}.protocol-table tbody th strong{color:#25344a;margin-bottom:10px;font-size:14px;font-weight:650;line-height:1.45;display:block}.protocol-table td.protocol-dose{color:#182c4a;letter-spacing:-.2px;font-size:15px;font-weight:700;line-height:1.55}.protocol-table tbody:last-child tr:last-child td,.protocol-table tbody:last-child tr:first-child th,.protocol-table tbody:last-child tr:first-child td{border-bottom:0}.protocol-origin{color:#245db2;white-space:nowrap;background:#edf4ff;border-radius:4px;width:fit-content;padding:3px 7px;font-size:10px;font-weight:600;line-height:1.5;display:inline-block}.community-origin{color:#916020;background:#fff4dc}.label-origin{color:#217055;background:#eaf8f1}.protocol-source .source-ref{margin:0 3px 5px 0}.protocol-details-button{color:#627389;align-items:center;gap:7px;padding:3px 0;font-size:11px;display:flex}.protocol-details-button span{font-size:15px}.protocol-context td{background:#f8faff!important;padding:18px 22px!important}.protocol-context td>div{grid-template-columns:150px 1fr;gap:15px;margin:6px 0;display:grid}.protocol-context strong{color:#3d526f;font-size:12px;font-weight:600}.protocol-context p{color:#5e6d83;font-size:12px;line-height:1.7}.table-scroll-hint{display:none}.science-grid{grid-template-columns:1fr 1fr;align-items:start;gap:24px;display:grid}.quiet-details{border-top:1px solid #e7ebf1;padding:15px 0;scroll-margin-top:80px;font-size:13px}.quiet-details:first-child{border-top:0}.quiet-details summary{color:#536580;cursor:pointer;font-size:13px;font-weight:550;line-height:1.6}.quiet-details summary>span{margin-left:6px}.quiet-details p,.quiet-details li{color:#606e82;margin-top:12px;font-size:13px;line-height:1.75}.quiet-details ul{padding-left:18px}.quiet-details p strong{color:#44566f;font-weight:600}.quiet-details:last-child{padding-bottom:0}.preclinical-protocols{margin-top:18px}.preclinical-protocols .protocol-table-block{margin-top:15px}.data-gap{color:#647185;background:#f7f9fc;border:1px dashed #d9e1ec;border-radius:7px;padding:16px;font-size:13px;line-height:1.65}.pk-facts{grid-template-columns:1fr 1fr;gap:20px;margin-bottom:7px;display:grid}.pk-facts>div>span,.molecule-stats span,.molecule-formula>span{color:#65707e;margin-bottom:7px;font-size:11px;font-weight:500;display:block}.pk-facts strong{color:#1d304f;letter-spacing:-.4px;font-size:21px;font-weight:700;line-height:1.35}.pk-facts>div:nth-child(2) strong{color:#60728c;letter-spacing:0;font-size:12px;font-weight:500;line-height:1.6}.pk-chart{width:360px;max-width:100%;margin-top:10px}.elimination-graph{width:360px;max-width:100%;height:164px;display:block;overflow:visible}.elimination-graph text{fill:#64748b;font-family:inherit;font-size:10px}.elimination-graph .chart-annotation{fill:#486ba3;font-size:9px}.chart-grid{stroke:#e8eef6;stroke-width:1px}.chart-line{fill:none;stroke:#427ce3;stroke-width:2.4px;stroke-linecap:round;stroke-linejoin:round}.chart-range{fill:#80aaf3;opacity:.18}.half-life-line{stroke:#b8cbee;stroke-dasharray:3 3;stroke-width:1px}.cursor-line{stroke:#74a0ed;stroke-width:1px}.cursor-point{fill:#2563eb;stroke:#fff;stroke-width:2px}.chart-controls{padding:6px 12px 0 36px}.chart-controls label{color:#636d7b;justify-content:space-between;font-size:11px;display:flex}.chart-controls output{color:#446db4;font-weight:600}.chart-controls input{accent-color:#437be0;cursor:pointer;width:100%;height:18px;margin:7px 0 9px;display:block}.pk-readout{flex-wrap:wrap;align-items:baseline;gap:7px;display:flex}.pk-readout strong{color:#2a5eaf;font-size:20px;font-weight:700}.pk-readout span{color:#677281;font-size:10px}.pk-readout [data-range-label]{flex-basis:100%;font-size:10px}.model-assumptions{margin-top:18px}.molecule-stats{grid-template-columns:1fr 1fr;gap:18px;display:grid}.molecule-stats strong{color:#324866;font-size:15px;font-weight:650;line-height:1.5;display:block}.molecule-chain{background:#f8faff;border:1px solid #edf1f8;border-radius:9px;margin:17px 0 18px;padding:12px 14px 8px}.molecule-chain svg{width:100%;max-width:400px;max-height:210px;display:block}.molecule-chain>span{text-align:right;color:#66707f;margin-top:2px;font-size:9px;display:block}.residue-bond{fill:none;stroke:#c8d7ed;stroke-width:2px}.residue circle{fill:#e0ecff;stroke:#bfd4f5;stroke-width:1px}.residue text{fill:#547ab3;font-family:inherit;font-size:10px;font-weight:600}.residue-1 circle{fill:#eae9fe;stroke:#d4d2f4}.residue-1 text{fill:#8078ba}.residue-2 circle{fill:#e1f5f6;stroke:#bfe6e9}.residue-2 text{fill:#4f959c}.molecule-formula{overflow-wrap:anywhere;margin:20px 0;padding-bottom:3px}.molecule-formula>strong{color:#3b5274;letter-spacing:1px;font-size:21px;font-weight:550;line-height:1.8}.molecule-formula sub{letter-spacing:0;font-size:.67em;line-height:0}.blend-chain{flex-wrap:wrap;gap:9px;margin-top:22px;display:flex}.blend-chain>span{color:#466caa;background:#f2f6ff;border:1px solid #cddbf3;border-radius:20px;padding:9px 14px;font-size:12px;font-weight:600;position:relative}.blend-chain small{color:#657289;font-size:10px;font-weight:400;display:block}.findings-list{border-top:1px solid #e7ebf1}.finding-item{border-bottom:1px solid #e7ebf1;align-items:flex-start;gap:12px;padding:17px 0;display:flex}.finding-item details{flex:1;min-width:0}.finding-item summary{cursor:pointer;justify-content:space-between;align-items:center;gap:16px;list-style:none;display:flex}.finding-item summary::-webkit-details-marker{display:none}.finding-item h3{letter-spacing:-.15px;color:#344a68;font-size:15px;font-weight:600;line-height:1.5}.finding-item summary>span{color:#637186;font-size:17px;font-weight:400}.finding-item details[open] summary>span{transform:rotate(45deg)}.finding-item p{color:#617085;max-width:900px;margin:12px 0 2px;font-size:14px;line-height:1.8}.finding-item>.source-ref{margin-top:2px}.finding-item .source-ref{flex-shrink:0}.interaction-item small{color:#676e79;margin-top:5px;font-size:10px;display:block}.expectation-groups{grid-template-columns:1fr 1fr;gap:24px;margin-top:20px;display:grid}.expectation-groups h3{color:#445b7b;letter-spacing:0;font-size:13px}.expectation-groups h4{letter-spacing:0;margin-top:14px;font-size:13px;font-weight:550;line-height:1.5}.research-check dl{font-size:12px;line-height:1.7}.research-check dl>div{grid-template-columns:80px 1fr;gap:15px;margin-top:8px;display:grid}.research-check dt{color:#646e7b}.research-check dd{overflow-wrap:anywhere;margin:0}.research-check a{color:#336ac7}.preparation-status{color:#647187;background:#f2f5fa;border-radius:5px;margin-bottom:14px;padding:4px 8px;font-size:11px;display:inline-block}.calculator-link{margin-top:20px;color:#2a60b9!important;background:#eff5ff!important;border-color:#cbdbf6!important}.detail-page .vial-list{gap:9px;margin:4px 0 18px}.detail-page .vial-card{border-color:#dee6f1;border-radius:8px;min-width:90px;padding:15px}.vial-card>strong{color:#304b73;font-size:25px;font-weight:700;display:inline-block}.vial-card>strong>small{color:#657283;margin-left:5px;font-size:12px;display:inline}.blend-ingredients{color:#606e82;margin:12px 0 0;font-size:11px}.blend-ingredients>div{justify-content:space-between;gap:15px;margin-top:4px;display:flex}.blend-ingredients dd{margin:0}.detail-page .source-ref{color:#4d71a6;background:#f4f7fc;border:1px solid #dce5f3;border-radius:4px;min-width:21px;height:21px;margin-left:5px;font-size:10px;font-weight:550}.detail-page .source-ref:hover{color:#255db3;background:#e8f0ff}.quick-use .source-ref{min-width:18px;height:18px;font-size:9px}.legacy-anchor{scroll-margin-top:82px;display:block}.reference-tools{border-bottom:1px solid #e1e8f2;justify-content:space-between;align-items:center;gap:15px;padding-bottom:14px;display:flex}.reference-total{color:#657183;white-space:nowrap;font-size:11px}.references-section .detail-section-heading p{color:#647082;margin-top:9px;font-size:12px}.source-filters{flex-wrap:wrap;gap:4px;display:flex}.source-filters button{color:#606d81;border-radius:5px;padding:5px 9px;font-size:11px}.source-filters button[aria-pressed=true]{color:#2b63bd;background:#edf3ff}.reference-tools .text-button{white-space:nowrap;padding-right:0;font-size:11px}.reference-entry{border-bottom:1px solid #e5eaf2;padding:0 0 13px}.reference-entry .source-card{border:0;padding:16px 0 9px;scroll-margin-top:85px}.reference-entry .source-title{color:#40546f;font-size:13px;line-height:1.6}.reference-entry .source-meta{color:#646e7d;font-size:10px}.reference-entry .source-number{color:#5d7395;background:#f6f9fe;border-color:#dbe5f3}.reference-entry .source-body p{color:#5c6d85;font-size:13px;line-height:1.8}.source-ai{color:#646e7d;letter-spacing:.5px}.source-verification{color:#537681;background:#eff8f9;border-radius:3px;margin-top:6px;padding:2px 5px;font-size:9px;display:inline-block}.source-verification.unverified{color:#6a707a;background:#f5f5f7}.source-alert{color:#b65353;margin-top:6px;font-size:11px;font-weight:550;display:block}.original-source{color:#4771b2;align-items:center;gap:5px;margin-left:39px;font-size:11px;display:inline-flex}.reference-entry:has(.source-card:target){background:#f3f7ff;border-radius:7px;box-shadow:0 0 0 8px #f3f7ff}.source-provenance{color:#656e7d!important;font-size:11px!important}.reference-entry [data-return-citation]{color:#476ea9;padding-left:0}.show-sources-button{text-align:center;color:#3c71c0;width:100%;padding:16px 10px 0;font-size:12px;font-weight:550;display:block}.related-section{padding:7px 0 16px}.related-list{margin-top:18px}@media (width<=1000px){.quick-facts{grid-template-columns:1fr 1fr}.quick-fact{min-height:135px}.quick-facts .uses-fact{grid-row:span 1}.science-grid{gap:16px}.detail-section{padding:22px}.section-nav{gap:24px}.detail-header h1{font-size:40px}}@media (width<=720px){.detail-page .breadcrumb{padding:20px 0}.detail-header{flex-wrap:wrap;align-items:flex-start;gap:15px}.detail-header h1{letter-spacing:-1.1px;font-size:34px}.detail-tagline{margin-top:7px;font-size:13px}.detail-actions{margin-top:0}.profile-description{margin-top:17px;font-size:13px;line-height:1.7}.profile-meta{gap:12px;margin-bottom:20px;font-size:11px}.quick-facts{gap:8px}.quick-fact{gap:9px;min-height:145px;padding:15px}.quick-fact>strong{letter-spacing:-.5px;font-size:20px}.quick-use strong{font-size:12px}.quick-use small{font-size:9px}.fact-label{font-size:11px}.quick-fact>small{font-size:10px}.section-nav{backdrop-filter:none;background:#fff;border-top:1px solid #edf1f6;gap:23px;height:53px;margin:19px -20px 22px;padding-inline:20px}.section-nav a{font-size:12px}.profile-sections{gap:17px}.detail-section{border-radius:10px;padding:20px 16px;scroll-margin-top:70px}.detail-section-heading{flex-wrap:wrap;gap:10px;margin-bottom:15px}.detail-section h2{font-size:21px}.section-note,.evidence-label{font-size:10px}.section-description{font-size:12px}.table-filters button{padding:7px 10px;font-size:11px}.table-scroll-hint{color:#66707f;margin-bottom:9px;font-size:10px;display:block}.protocol-table{min-width:800px}.protocol-table th,.protocol-table td{padding:15px 12px}.protocol-table thead th:first-child,.protocol-table tbody th{z-index:1;background:#fff;position:sticky;left:0;box-shadow:1px 0 #e1e8f2}.protocol-table thead th:first-child{background:#f7f9fc}.protocol-table th:first-child{width:165px}.protocol-table tbody th strong{font-size:13px}.protocol-table td.protocol-dose{font-size:14px}.table-note{font-size:10px}.science-grid{grid-template-columns:1fr;gap:17px}.pk-facts strong{font-size:20px}.pk-chart{margin-inline:auto}.pk-facts>div:nth-child(2) strong{font-size:11px}.elimination-graph{height:164px}.chart-controls input{height:26px}.molecule-stats strong{font-size:14px}.molecule-formula>strong{font-size:20px}.quiet-details summary,.quiet-details p,.quiet-details li{font-size:12px}.finding-item{gap:8px}.finding-item h3{font-size:14px}.finding-item p{font-size:13px}.expectation-groups{grid-template-columns:1fr;gap:20px}.research-check dl>div{grid-template-columns:60px 1fr}.reference-tools{display:block}.reference-tools .text-button{margin-top:7px;padding-left:0}.reference-entry .source-title{font-size:12px}.source-filters button{padding:5px 7px;font-size:10px}.reference-entry .source-body{padding-left:0}.reference-entry .source-body p{font-size:12px}.detail-page .source-ref{min-width:22px;min-height:22px}.quick-use .source-ref{min-width:19px;min-height:19px}.references-section .detail-section-heading{align-items:start}.protocol-context td>div{grid-template-columns:130px 1fr}}@media (prefers-reduced-motion:reduce){.detail-page *{scroll-behavior:auto!important}}.detail-page.wrap{max-width:1320px}.detail-page .breadcrumb{padding-block:26px}.profile-description{max-width:1040px;line-height:1.85}.quick-facts{gap:18px}.quick-fact{border-top:4px solid #5d83d3;border-radius:14px;min-height:158px;padding:24px;box-shadow:0 3px 12px #243e6710}.quick-fact:nth-child(2){background:#f6fcfa;border-top-color:#3ba394}.quick-fact:nth-child(3){background:#fbf9ff;border-top-color:#9581d7}.quick-fact:nth-child(4){background:#fffcf6;border-top-color:#d3a151}.quick-fact>strong{font-size:26px;line-height:1.3}.section-nav{background:#fff;border:1px solid #dce5f2;border-radius:12px;align-items:center;gap:22px;height:66px;margin-block:30px;padding:8px 14px;top:10px;overflow:visible;box-shadow:0 4px 16px #25426c0d}.section-nav-label{color:#5b6b82;white-space:nowrap;padding-left:5px;font-size:10px;font-weight:650}.section-nav-links{scrollbar-width:thin;align-items:center;gap:7px;width:100%;height:100%;display:flex;overflow-x:auto}.section-nav .section-nav-links a{white-space:nowrap;color:#52647d;border:0;border-radius:7px;height:auto;padding:10px 12px;font-size:12px;line-height:1.5}.section-nav .section-nav-links a[aria-current=location]{color:#275bac;background:#edf3ff;font-weight:650}.section-select-label{display:none}.profile-sections{gap:36px}.science-grid{gap:28px}.science-grid>.detail-section{height:auto}.detail-section{--section-accent:#537bc9;--section-surface:#f5f8ff;border:1px solid #d8e2ef;border-top:4px solid var(--section-accent);border-radius:15px;padding:32px;scroll-margin-top:100px;overflow:hidden;box-shadow:0 4px 18px #20395908}.detail-section>.detail-section-heading{background:var(--section-surface);border-bottom:1px solid #e0e7f0;min-height:94px;margin:-32px -32px 26px;padding:24px 32px}.detail-section h2{font-size:25px;line-height:1.3}.detail-section-heading p{max-width:760px;margin-top:7px;font-size:12px;line-height:1.7}.section-kicker{letter-spacing:.8px;text-transform:uppercase;color:var(--section-accent);margin-bottom:7px;font-size:10px;font-weight:650;display:block}#pharmacokinetics{--section-accent:#32998c;--section-surface:#f3fbf9}#molecular{--section-accent:#9274cd;--section-surface:#faf7ff}#research{--section-accent:#4b8fa5;--section-surface:#f3fafc}#safety{--section-accent:#cd7d74;--section-surface:#fff8f6}#interactions{--section-accent:#c59a47;--section-surface:#fffbf2}#reconstitution{--section-accent:#4b9e9d;--section-surface:#f4fbfa}#vials{--section-accent:#8c84bd;--section-surface:#f9f8fd}#measurement{--section-accent:#5588c9;--section-surface:#f3f8ff}#sources{--section-accent:#8a9db6;--section-surface:#f7f9fc}.protocol-toolbar{justify-content:space-between;align-items:center;gap:16px;margin-bottom:16px;display:flex}.protocol-row-count{color:#5b6e89;white-space:nowrap;font-size:11px}.table-filters{flex-wrap:wrap;gap:6px;margin:0;display:flex}.table-filters button{border:1px solid #e0e7f1;border-radius:7px;padding:8px 12px;font-size:12px}.table-filters button[aria-pressed=true]{color:#2c5da8;background:#edf3ff;border-color:#bed0f0}.route-filters{flex-wrap:wrap;align-items:center;gap:6px;margin:0 0 18px;display:flex}.route-filters>span{color:#5f708a;margin-right:7px;font-size:11px}.route-filters button{color:#536783;background:#f4f6fa;border:1px solid #0000;border-radius:6px;padding:6px 10px;font-size:11px}.route-filters button[aria-pressed=true]{color:#26776d;background:#e9f5f2;border-color:#b8dcd4}.protocol-table{min-width:1000px}.protocol-table thead th{background:#f1f5fc;padding:14px 16px;font-size:11px}.protocol-table th:first-child{width:12%}.protocol-table th:nth-child(2){width:20%}.protocol-table th:nth-child(3){width:15%}.protocol-table th:nth-child(4){width:27%}.protocol-table th:nth-child(5){width:15%}.protocol-table th:nth-child(6){width:11%}.protocol-table tbody th,.protocol-table tbody td{vertical-align:top;background:#fff;padding:22px 16px;font-size:13px;line-height:1.65}.protocol-table tbody:nth-of-type(2n)>tr:first-child>td,.protocol-table tbody:nth-of-type(2n)>tr:first-child>th{background:#fafcff}.protocol-table tbody tr:hover>td,.protocol-table tbody tr:hover>th{background:#f3f7fe}.protocol-table td.protocol-dose{color:#193b6b;font-size:17px;font-weight:750;line-height:1.55}.protocol-goal strong{color:#394f6b;margin-bottom:9px;font-size:13px;font-weight:600;line-height:1.6;display:block}.protocol-origin{padding:3px 8px;font-size:10px}.protocol-route>small{color:#5e6f86;overflow-wrap:anywhere;margin-top:8px;font-size:10px;font-weight:400;line-height:1.5;display:block}.route-badge{color:#3564af;white-space:nowrap;background:#eaf1fe;border-radius:6px;padding:4px 9px;font-size:12px;font-weight:700;display:inline-block}.route-oral{color:#537544;background:#eef7eb}.route-iv{color:#795cae;background:#efeafb}.route-im{color:#3f7689;background:#e9f5f8}.route-topical,.route-nasal{color:#9b5c7e;background:#fceef5}.route-unspecified{color:#5d6c82;background:#eef1f5}.protocol-details-button{margin-top:6px;font-size:11px}.protocol-context td>div{grid-template-columns:160px 1fr;gap:20px}.table-note{max-width:980px;margin-top:22px;line-height:1.8}.pk-facts{gap:24px;margin-bottom:20px}.pk-facts strong{font-size:24px}.pk-chart{margin-block:20px}.sequence-section{border-top:1px solid #e4e1ee;margin-top:24px;padding-top:22px}.sequence-heading{justify-content:space-between;align-items:center;gap:20px;display:flex}.sequence-heading h3{color:#59467e;letter-spacing:0;font-size:16px;font-weight:650}.copy-sequence{color:#7254a7;padding:5px 8px;font-size:11px}.molecule-chain{background:#fbf9ff;border-color:#e3ddef;margin:16px 0;padding:16px 12px 10px}.molecule-chain svg{max-width:480px;max-height:230px}.residue text{font-size:12px}.modified-residue text{font-size:8px}.modified-residue circle{fill:#e6d9fc;stroke:#b89bdc;stroke-width:1.5px}.sequence-text{overflow-wrap:anywhere;white-space:normal;word-break:break-word;color:#674e92;background:#f6f3fc;border:1px solid #e5dff2;border-radius:8px;padding:13px;font-size:12px;line-height:1.9;display:block}.sequence-note{color:#686077;margin-top:12px;font-size:11px;line-height:1.8}.sequence-citations{flex-wrap:wrap;align-items:center;gap:4px;margin-top:12px;display:flex}.sequence-citations>span{color:#686077;margin-right:5px;font-size:10px}.sequence-gap{color:#6a6477;background:#f8f6fc;border-radius:8px;margin-top:15px;padding:13px 15px;font-size:12px;line-height:1.8}.finding-item{padding:23px 0}.finding-item h3{font-size:16px;line-height:1.6}.finding-item p{line-height:1.85}.quiet-details{padding-block:19px}.molecule-formula{margin-block:24px}.device-cards{grid-template-columns:repeat(3,1fr);gap:20px;display:grid}.device-card{background:#f8fbff;border:1px solid #dce4f0;border-radius:12px;min-width:0;padding:24px}.device-type{color:#426da7;margin-bottom:12px;font-size:11px;font-weight:650;display:block}.device-card h3{color:#244f8c;letter-spacing:-.5px;font-size:23px;font-weight:750;line-height:1.3}.device-card>p{color:#5b6e89;margin-top:9px;font-size:11px;line-height:1.8}.device-card dl{margin:20px 0;font-size:11px}.device-card dl>div{border-bottom:1px solid #e1e9f4;justify-content:space-between;gap:12px;padding:10px 0;display:flex}.device-card dt{color:#5d6f88}.device-card dd{color:#2f4f7b;text-align:right;white-space:nowrap;margin:0;font-weight:600}.syringe-card{background:#f7fcfa;border-color:#d9eae4}.syringe-card .device-type{color:#3b8877}.syringe-card h3{color:#2f7566}.volume-card{background:#fbf9ff;border-color:#e4dcf0}.volume-card .device-type{color:#8065ac}.volume-card h3{color:#71519e}.device-bottom{border-top:1px solid #e2e9f3;justify-content:space-between;gap:32px;margin-top:24px;padding-top:22px;display:flex}.device-bottom>p{color:#5e6f86;max-width:850px;font-size:12px;line-height:1.8}.device-bottom>details{color:#4a6e9c;min-width:175px;font-size:11px;line-height:1.8}.device-bottom summary{cursor:pointer}.device-bottom a{color:#3b67a7;margin-top:9px;display:block}.device-bottom small{color:#64748b;margin-top:10px;display:block}.detail-page .vial-list{gap:12px}.detail-page .vial-card{padding:18px}.concentration-example{--section-accent:#547ec5;--section-surface:#f4f8ff}@media (width>=1100px){.section-nav-links{justify-content:space-between}}@media (width<=1000px){.section-nav-label{display:none}.section-nav{gap:0}.section-nav .section-nav-links a{padding-inline:10px}.detail-section{padding:26px}.detail-section>.detail-section-heading{margin:-26px -26px 24px;padding:23px 26px}.device-cards{gap:12px}.device-card{padding:18px}.device-card h3{font-size:20px}.device-card dl>div{display:block}.device-card dd{text-align:left;margin-top:4px}.quick-fact>strong{font-size:24px}}@media (width<=720px){.detail-page.wrap{padding-inline:20px}.quick-facts{gap:12px}.quick-fact{min-height:155px;padding:18px}.quick-fact>strong{font-size:22px}.profile-description{line-height:1.85}.profile-meta{margin-bottom:25px}.section-nav{border-radius:10px;height:auto;min-height:68px;margin:24px 0;padding:10px 14px;top:8px;overflow:visible}.section-nav-links{display:none}.section-select-label{color:#64748b;justify-content:space-between;align-items:center;gap:14px;width:100%;font-size:11px;font-weight:600;display:flex}.section-select-label select{color:#315e9c;background:#f6f9ff;border:1px solid #cbdaf0;border-radius:6px;min-width:190px;max-width:65%;height:40px;padding:0 10px;font-size:14px}.profile-sections,.science-grid{gap:28px}.detail-section{border-radius:12px;padding:22px 18px;scroll-margin-top:104px}.detail-section>.detail-section-heading{min-height:90px;margin:-22px -18px 24px;padding:21px 18px}.detail-section h2{font-size:23px}.section-kicker{margin-bottom:6px;font-size:9px}.detail-section-heading p{font-size:11px}.protocol-toolbar{align-items:flex-start;gap:10px}.table-filters{gap:5px}.table-filters button{padding:7px 9px;font-size:10px}.protocol-row-count{padding-top:9px;font-size:10px}.route-filters>span{width:100%;margin-bottom:3px}.protocol-table{min-width:940px}.protocol-table th:first-child{width:110px!important}.protocol-table td.protocol-dose{font-size:16px}.protocol-table tbody th,.protocol-table tbody td{padding:20px 13px}.protocol-table thead th:first-child,.protocol-table tbody th{background:#fff;box-shadow:2px 0 4px #233c6510}.protocol-table tbody:nth-of-type(2n)>tr:first-child>th{background:#fafcff}.protocol-context td>div{grid-template-columns:130px 1fr}.table-note{font-size:11px}.pk-facts strong{font-size:22px}.device-cards{grid-template-columns:1fr;gap:17px}.device-card{padding:22px}.device-card h3{font-size:24px}.device-card dl>div{display:flex}.device-card dd{text-align:right;margin:0}.device-bottom{display:block}.device-bottom details{margin-top:18px}.device-bottom>p{font-size:11px}.device-guide>.detail-section-heading{display:block}.device-guide .button{margin-top:17px}.finding-item{padding:21px 0}.finding-item h3{font-size:15px}.sequence-text{font-size:11px;line-height:2}.sequence-heading h3{font-size:15px}.molecule-chain{padding:13px 8px}.sequence-note{font-size:11px}.detail-page .vial-card{padding:17px}.detail-page .vial-list{gap:10px}}.protocol-empty{color:#52647d;background:#f7faff;border:1px solid #dce5f2;border-radius:9px;margin-top:12px;padding:22px;font-size:13px}.protocol-empty button{color:#285fa9;margin-left:8px;font-weight:600;text-decoration:underline}.use-overview{--section-accent:#5280c8;--section-surface:#f6f9ff}.use-overview>.detail-section-heading{min-height:86px;margin-bottom:26px}.use-columns{grid-template-columns:1fr 1fr;gap:26px;display:grid}.use-column{background:#f7fbff;border:1px solid #d9e6ef;border-radius:12px;flex-direction:column;min-width:0;padding:26px;display:flex}.use-column-heading{flex-wrap:wrap;justify-content:space-between;align-items:center;gap:12px;margin-bottom:22px;display:flex}.use-column h3{letter-spacing:-.35px;color:#244d7d;font-size:20px}.use-evidence{color:#3d6595;background:#e9f2fd;border-radius:5px;padding:5px 8px;font-size:10px;font-weight:600;line-height:1.5}.use-item{border-top:1px solid #e0e8f2;padding:17px 0}.use-column-heading+.use-item{border-top:0;padding-top:0}.use-item-title{flex-wrap:wrap;align-items:center;gap:10px;display:flex}.use-item h4{letter-spacing:-.15px;color:#243e60;font-size:17px;font-weight:650;line-height:1.5}.use-item p{color:#536780;margin-top:8px;font-size:13px;line-height:1.85}.use-kind{color:#607897;background:#fff;border:1px solid #d5e2f1;border-radius:4px;padding:2px 5px;font-size:9px}.use-kind.approved-use{color:#25725d;background:#edf9f2;border-color:#cce6d8}.use-status{border-top:1px solid #dce6f1;margin-top:auto;padding-top:16px}.use-status>strong{color:#60748d;font-size:10px;font-weight:600}.use-status>p{color:#536780;margin-top:5px;font-size:12px;line-height:1.75}.use-detail-link{color:#3468a5;border-top:1px solid #dce6f1;justify-content:space-between;align-items:center;margin-top:20px;padding-top:15px;font-size:12px;font-weight:600;display:flex}.community-uses{background:#fffcf5;border-color:#ecdfc7}.community-uses h3{color:#876321}.community-uses .use-evidence{color:#89672a;background:#f9edcf}.community-uses .use-item{border-color:#ece4d4}.community-uses .use-item h4{color:#6c542b}.community-uses .use-item p{color:#756950}.community-use-note{color:#83704e;margin-top:auto;padding-top:14px;font-size:12px;line-height:1.8}.community-uses .use-detail-link{color:#8b6b2e;border-color:#eadfc8}.use-next-links{border-top:1px solid #e2e9f2;flex-wrap:wrap;gap:12px;margin-top:25px;padding-top:23px;display:flex}.use-next-links a{color:#4a6b97;background:#f7f9fd;border:1px solid #e1e8f2;border-radius:7px;flex:1;justify-content:space-between;align-items:center;gap:22px;min-width:160px;padding:10px 14px;font-size:12px;display:flex}.use-next-links a:hover{background:#edf4ff;border-color:#9fbadf}.secondary-facts{grid-template-columns:repeat(3,minmax(0,1fr))}.secondary-facts .quick-fact{min-height:130px;padding:22px}.secondary-facts .quick-fact>strong{font-size:24px}.kinetics-grid{grid-template-columns:1.1fr 1fr}.pk-model-select{color:#62748d;justify-content:space-between;align-items:center;gap:16px;margin-bottom:22px;font-size:11px;display:flex}.pk-model-select select{min-width:0;max-width:80%;font:inherit;color:#365d90;background:#f6f9fd;border:1px solid #ccd9e9;border-radius:6px;padding:9px 28px 9px 10px;font-size:12px}.pk-evidence{flex-wrap:wrap;align-items:center;gap:12px;margin-bottom:21px;display:flex}.pk-evidence>span{color:#317e66;background:#eaf6f1;border-radius:5px;padding:5px 8px;font-size:10px;font-weight:650}.pk-evidence>strong{color:#9b7434;font-size:11px;font-weight:500}.pk-evidence-animal>span{color:#636e9c;background:#eef1fb}.pk-evidence-reference>span,.pk-evidence-inferred>span{color:#967128;background:#fff1d4}.pk-evidence-note{color:#7b6a4b;background:#fffdf8;border:1px solid #e5e4d9;border-radius:8px;margin:18px 0;padding:14px 16px;font-size:12px;line-height:1.8}.pk-facts{grid-template-columns:1.25fr 1fr}.pk-facts>div>strong{font-size:25px;line-height:1.4;display:block}.pk-facts .source-ref{margin:8px 4px 0 0}.pk-chart{width:100%;max-width:600px;margin:24px 0 0}.elimination-graph{aspect-ratio:360/220;width:100%;max-width:600px;height:auto}.elimination-graph .chart-annotation{font-size:9px}.pk-chart .chart-controls{padding-top:0}.chart-controls label{font-size:12px}.chart-controls input{height:25px;margin:10px 0}.pk-readout strong{font-size:27px}.pk-readout span{font-size:11px}.pk-curve-caption{color:#748198;margin:16px 0 24px;font-size:11px;line-height:1.8}.estimated-curve .chart-line{stroke:#b58c42;stroke-dasharray:5 4}.estimated-curve .chart-range{fill:#d2ae66}.estimated-curve .cursor-point{fill:#ad843d}.estimated-curve .pk-readout strong{color:#967128}.estimated-curve input{accent-color:#b58c42}.range-boundary{stroke-width:1.6px;stroke-dasharray:4 3}.pk-interpretation{color:#61758c;background:#f4f9fb;border-left:3px solid #86bfb4;margin:20px 0;padding:14px 16px;font-size:12px;line-height:1.8}.pk-interpretation>strong{color:#3b7a70;margin-bottom:5px;font-size:11px;display:block}.component-kinetics{gap:10px;margin:20px 0;display:grid}.component-kinetics a{background:#f8fbfd;border:1px solid #dce7ee;border-radius:8px;grid-template-columns:1fr 1.5fr;align-items:center;gap:6px 12px;padding:15px;display:grid}.component-kinetics strong{color:#3a617e;font-size:13px}.component-kinetics span{color:#546b82;text-align:right;font-size:12px}.component-kinetics small{color:#7b8a9e;text-align:right;grid-column:1/-1;font-size:10px}.profile-meta{margin-bottom:4px}.profile-meta details>p{max-width:950px}.section-nav{gap:14px}.section-nav .section-nav-links a{padding-inline:10px}@media (width<=1000px){.use-column{padding:22px}.use-columns{gap:18px}.use-column h3{font-size:18px}.use-item h4{font-size:16px}.secondary-facts .quick-fact>strong{font-size:21px}.pk-facts{grid-template-columns:1fr}.pk-facts>div:nth-child(2) strong{font-size:12px}.kinetics-grid{grid-template-columns:1fr 1fr}}@media (width<=720px){.use-columns{grid-template-columns:1fr;gap:20px}.use-column{padding:22px 18px}.use-column h3{font-size:19px}.use-column-heading{margin-bottom:20px}.use-item h4{font-size:16px}.use-item p{font-size:13px}.use-overview>.detail-section-heading{margin-bottom:22px}.use-next-links{gap:9px}.use-next-links a{min-width:100%;padding:12px 14px;font-size:12px}.secondary-facts{grid-template-columns:1fr 1fr;gap:12px}.secondary-facts .quick-fact{min-height:138px;padding:18px}.secondary-facts .quick-fact:last-child{grid-column:1/-1;min-height:100px}.secondary-facts .quick-fact>strong{font-size:21px}.kinetics-grid{grid-template-columns:1fr}.pk-chart{margin:20px 0 0}.elimination-graph{aspect-ratio:360/220;width:100%;height:auto}.pk-facts{grid-template-columns:1fr 1fr;gap:18px}.pk-facts>div>strong{font-size:22px}.pk-facts>div:nth-child(2) strong{font-size:11px}.pk-model-select{display:block}.pk-model-select select{width:100%;max-width:100%;margin-top:8px;font-size:12px;display:block}.pk-evidence{gap:7px}.pk-evidence-note{padding:13px;font-size:11px}.pk-readout strong{font-size:25px}.pk-curve-caption{font-size:10px}.chart-controls label,.pk-interpretation{font-size:11px}.component-kinetics a{grid-template-columns:1fr}.component-kinetics span,.component-kinetics small{text-align:left}}[hidden]{display:none!important}.detail-page.profile-v2.wrap{padding-inline:40px;max-width:1120px;padding-bottom:72px}.profile-v2 .detail-header{align-items:center;gap:24px;margin-bottom:14px}.profile-v2 .detail-header h1{letter-spacing:-1.8px;margin-top:10px;font-size:48px;line-height:1.15}.profile-v2 .detail-tagline{color:#52647a;margin-top:10px;font-size:15px;line-height:1.65}.profile-v2 .profile-introduction{color:#425772;max-width:820px;margin:20px 0;font-size:16px;line-height:1.85}.profile-identity{flex-wrap:wrap;align-items:baseline;gap:24px;margin-bottom:30px;display:flex}.profile-identity>details{color:#586d88;flex:1;min-width:190px;font-size:12px}.profile-identity summary{cursor:pointer;width:fit-content;min-height:32px}.profile-identity p{max-width:820px;margin:10px 0;line-height:1.85}.profile-jumpnav{top:var(--site-header-height);z-index:15;backdrop-filter:blur(14px);background:#fffffff5;border-bottom:1px solid #dae3ee;gap:8px;margin:0 0 38px;padding:12px 0 0;display:flex;position:sticky}.profile-jumpnav a{text-align:center;color:#526780;white-space:nowrap;border-bottom:3px solid #0000;border-radius:6px 6px 0 0;flex:1;padding:16px 10px 18px;font-size:14px;font-weight:600}.profile-jumpnav a:hover{color:#245aac;background:#f6f9fd}.profile-jumpnav a[aria-current=location]{color:#215ca9;background:#f3f7fd;border-bottom-color:#2867bd}.profile-jumpnav a:focus-visible{outline-offset:-3px;outline:2px solid #3675cd}.profile-v2 [data-profile-section]{outline-offset:7px;scroll-margin-top:85px}.profile-v2 [data-profile-section]>.detail-section,.profile-v2 .preparation-reference>.detail-section,.profile-v2 .research-reference>.detail-section{margin:0 0 40px}.profile-v2 .detail-section{border:1px solid #e0e7ef;border-top:3px solid var(--section-accent,#527fc4);box-shadow:none;border-radius:12px;padding:30px 32px;scroll-margin-top:90px;overflow:visible}.profile-v2 .detail-section>.detail-section-heading{background:0 0;border:0;align-items:center;gap:16px;min-height:0;margin:0 0 26px;padding:0}.profile-v2 .detail-section h2{letter-spacing:-.7px;color:#1e344f;font-size:25px}.profile-v2 .detail-section-heading p{color:#60728a;margin-top:10px;font-size:13px;line-height:1.8}.profile-v2 .detail-section-heading .section-action{color:#2a62a7;white-space:nowrap;font-size:12px}.profile-v2 .section-kicker{display:none}.profile-v2 .uses-group{border-top:1px solid #e4eaf1;padding-top:24px}.profile-v2 .uses-group+.uses-group{margin-top:30px}.profile-v2 .uses-group>h3{letter-spacing:0;color:#416385;margin-bottom:15px;font-size:14px;line-height:1.7}.profile-v2 .reported-uses>h3{color:#8a651e}.profile-v2 .uses-group>h3>span{color:#8c7650;margin-left:9px;font-size:11px;font-weight:400}.profile-v2 .use-answer{border-bottom:1px solid #edf0f5;padding:16px 0}.profile-v2 .use-answer:last-of-type{border-bottom:0}.profile-v2 .use-answer>div{flex-wrap:wrap;align-items:center;gap:10px;display:flex}.profile-v2 .use-answer h4{color:#263e5c;font-size:17px;font-weight:650;line-height:1.55}.profile-v2 .use-answer p{color:#526680;max-width:850px;margin-top:10px;font-size:14px;line-height:1.85}.profile-v2 .use-answer summary{cursor:pointer;justify-content:space-between;align-items:center;gap:20px;list-style:none;display:flex}.profile-v2 .use-answer summary::-webkit-details-marker{display:none}.profile-v2 .use-answer summary>span{color:#8a7552;font-size:20px;font-weight:400}.profile-v2 .use-answer[open] summary>span{transform:rotate(45deg)}.profile-v2 .use-disclaimer{color:#806e4e;margin-top:20px;font-size:12px;line-height:1.8}.profile-v2 .evidence-verdict{color:#315f91;letter-spacing:-.4px;margin-bottom:15px;font-size:27px;display:block}.profile-v2 .evidence-context,.profile-v2 .safety-preview p{max-width:870px;font-size:14px;line-height:1.85}.profile-v2 .quiet-details{border-top:1px solid #e5eaf0;margin-top:18px;padding:20px 0}.profile-v2 .quiet-details>summary{color:#456386;cursor:pointer;font-size:14px;line-height:1.65}.profile-v2 .quiet-details>p,.profile-v2 .quiet-details li{margin-top:12px;font-size:13px;line-height:1.85}.profile-v2 .overview-facts{border:1px solid #e1e8f0;border-radius:12px;margin:0 0 40px;padding:8px 28px}.profile-v2 .overview-facts a{border-bottom:1px solid #e4eaf1;grid-template-columns:140px 1fr;gap:8px 25px;padding:22px 0;display:grid}.profile-v2 .overview-facts a:last-child{border-bottom:0}.profile-v2 .overview-facts span{color:#687d95;font-size:13px}.profile-v2 .overview-facts strong{color:#315880;font-size:17px;font-weight:600}.profile-v2 .overview-facts small{color:#687d95;grid-column:2;font-size:11px;line-height:1.7}.profile-fold{background:#fff;border:1px solid #dfe6ee;border-radius:12px;margin:0 0 40px;padding:0 28px;scroll-margin-top:90px}.profile-fold>summary{cursor:pointer;color:#304f72;padding:24px 0;font-size:16px;font-weight:650;line-height:1.7}.profile-fold>summary>span{color:#748398;margin-left:12px;font-size:12px;font-weight:400}.profile-v2 .profile-fold>.detail-section{border:0;border-radius:0;padding:10px 0 25px}.profile-v2 .profile-fold>.detail-section>.detail-section-heading{display:none}.profile-v2 .expectation-columns,.profile-v2 .interaction-rows,.profile-v2 .storage-grid,.profile-v2 .cycle-grid,.profile-v2 .device-cards{display:block}.profile-v2 .expectation-columns>div+div{margin-top:28px}.profile-v2 .reported-expectations{background:#fffcf5;border-color:#eee3cd;padding:24px}.profile-v2 .cycle-card{background:0 0;border:0;border-bottom:1px solid #e5eaf0;border-radius:0;padding:20px 0}.profile-v2 .cycle-card dl>div{grid-template-columns:140px 1fr}.profile-v2 .cycle-card dd{font-size:14px}.profile-v2 .cycle-card h4{font-size:15px}.profile-v2 .storage-grid article{margin:16px 0;padding:20px 24px}.profile-v2 .interaction-row{background:0 0;border:0;border-bottom:1px solid #e5eaf0;border-radius:0;padding:24px 0}.profile-v2 .interaction-row p{max-width:880px;font-size:14px}.profile-v2 .device-card{margin:20px 0;padding:24px}.profile-v2 .device-card dl{max-width:500px}.profile-v2 .device-bottom{display:block}.profile-v2 .device-bottom details{margin-top:18px}.profile-v2 .finding-item{padding:23px 0}.profile-v2 .finding-item p{font-size:14px;line-height:1.85}.profile-v2 .protocol-table{min-width:940px}.profile-v2 .protocol-table td.protocol-dose{font-size:17px}.profile-v2 .protocol-source-context{background:0 0;border:0;border-top:1px solid #e5eaf0;margin-top:0;padding:16px 0}.profile-v2 .protocol-source-context p{margin-top:12px;font-size:13px;line-height:1.8}.profile-v2 .protocol-table tbody th,.profile-v2 .protocol-table tbody td{padding:24px 14px}.profile-v2 .pk-chart{width:100%;max-width:720px;margin:24px 0}.profile-v2 .pk-chart svg{width:100%;height:auto;max-height:300px}.profile-v2 .pk-facts{max-width:730px}.profile-v2 .pk-facts strong{font-size:28px}.profile-v2 .vial-list{flex-wrap:wrap;gap:12px;display:flex}.profile-v2 .vial-card{background:#fafbfe;border:1px solid #e0e7f0;border-radius:8px;min-width:100px;padding:15px 20px}.profile-v2 .source-ref{justify-content:center;align-items:center;min-width:25px;min-height:25px;font-size:11px;display:inline-flex}.profile-v2 .related-section{border-top:1px solid #e1e7f0;margin-top:44px;padding-top:30px}.profile-v2 .related-section h2{margin-bottom:18px;font-size:18px}.vial-calculator .calculator-layout{margin-top:24px;display:block}.vial-calculator .calc-form{border:0;border-radius:0;max-width:740px;padding:0}.vial-calculator .calc-output{margin-top:30px}.vial-calculator .calc-output .result-panel{background:#f4f8ff;border:1px solid #c8dafa;border-radius:10px;padding:26px 30px}.vial-calculator .field-label{font-size:13px}.vial-calculator .field-label>span{font-size:11px}.vial-calculator .form-input,.vial-calculator .input-unit{background:#fff;min-height:48px}.vial-calculator .field-help{font-size:12px;line-height:1.8}.vial-calculator .calc-section+.calc-section{margin-top:30px;padding-top:30px}.vial-calculator .step-heading h2{letter-spacing:-.3px;font-size:20px!important}.vial-calculator .step-heading>span{color:#3464a6;background:#eaf1fc;border-color:#c7d8f2;font-size:12px}.vial-calculator #calc-placeholder p{max-width:none;margin-block:12px 18px}.vial-calculator #calc-placeholder h2{letter-spacing:-.4px;margin-top:15px;font-size:21px}.vial-calculator .units-note{margin:22px 0 0}.vial-calculator .units-note p{max-width:830px;font-size:12px}.vial-calculator .calc-output>.inline-note{display:none}.vial-calculator .result-fine{max-width:820px;font-size:11px}.vial-calculator .math-breakdown{max-width:650px}.vial-calculator .math-breakdown>div{padding:13px 0;font-size:13px}.vial-calculator .result-main strong{color:#255fad;font-size:60px}.vial-calculator .result-main>span{font-size:14px}.vial-calculator .syringe-chart{max-width:620px}.vial-calculator .preset-row .preset{padding:8px 13px;font-size:13px}.vial-calculator .preset-row .preset.selected{color:#245ca7;background:#eaf2ff;border-color:#81a6de}.vial-calculator .math-mode>.text-button{font-size:12px}.vial-calculator .increment-callout{justify-content:flex-start;font-size:13px}.vial-calculator .increment-callout span:last-child{font-size:12px}.tool-page:has(.vial-calculator){max-width:1000px;padding-bottom:65px}.tool-page>.profile-fold{margin-top:36px}.source-dialog{color:#344c6b;border:1px solid #d5e0ee;border-radius:16px;width:min(660px,100vw - 32px);max-height:85dvh;margin:auto;padding:26px 30px;overflow:auto;box-shadow:0 25px 100px #18325130}.source-dialog::backdrop{backdrop-filter:blur(3px);background:#14294066}.source-dialog-top{border-bottom:1px solid #e2e9f2;justify-content:space-between;align-items:center;margin-bottom:24px;padding-bottom:15px;display:flex}.source-dialog-top>span{color:#677e99;font-size:13px}.source-dialog-top button{color:#385675;cursor:pointer;background:#f7faff;border:1px solid #dce5ef;border-radius:8px;width:40px;height:40px;font-size:17px}.source-dialog h2{letter-spacing:-.5px;color:#243d5d;margin:10px 0 15px;font-size:23px;line-height:1.5}.source-preview-number{color:#326ab1;font-size:12px;font-weight:600}.source-dialog .source-meta,.source-dialog .source-verification{margin:12px 0;font-size:12px;line-height:1.8;display:block}.source-dialog .source-verification{color:#38618e;background:#f0f5fc;border-radius:6px;padding:10px 13px}.source-dialog .source-verification.unverified{color:#80652f;background:#fff8e9}.source-dialog .source-body{border-top:1px solid #e3e9f1;padding:20px 0}.source-dialog .source-body p{margin:10px 0 20px;font-size:14px;line-height:1.85}.source-dialog .source-ai{color:#7b8b9e;letter-spacing:.6px;font-size:10px}.source-dialog .original-source{color:#275ea8;border:1px solid #c5d7ef;border-radius:7px;align-items:center;gap:8px;margin-top:6px;padding:12px 16px;font-size:13px;display:inline-flex}.source-report p{margin:16px 0;font-size:13px;line-height:1.85}.source-report a{color:#2864b1;font-size:13px}.source-limit{color:#7d6741;border-left:3px solid #ccb078;padding-left:14px}.source-dialog .source-alert{color:#976030;margin:14px 0;font-size:13px;line-height:1.8;display:block}@media (width<=720px){.detail-page.profile-v2.wrap{padding-inline:18px}.profile-v2 .breadcrumb{padding-block:22px}.profile-v2 .detail-header{flex-wrap:wrap;align-items:flex-start;gap:18px}.profile-v2 .detail-header h1{letter-spacing:-1.2px;font-size:38px}.profile-v2 .detail-actions{gap:8px;margin:0}.profile-v2 .detail-tagline{font-size:14px}.profile-v2 .profile-introduction{margin-block:20px;font-size:15px;line-height:1.85}.profile-v2 .profile-identity{gap:12px;margin-bottom:17px}.profile-jumpnav{top:var(--site-header-height);gap:0;margin:0 -18px 26px;padding:5px 10px 0}.profile-jumpnav a{padding:17px 5px 16px;font-size:12px}.profile-v2 .detail-section{border-radius:10px;padding:24px 21px}.profile-v2 .detail-section>.detail-section-heading{flex-wrap:wrap;align-items:flex-start;gap:10px;min-height:0;margin:0 0 24px;padding:0}.profile-v2 .detail-section h2{font-size:23px}.profile-v2 .detail-section-heading .section-action{font-size:12px}.profile-v2 [data-profile-section]>.detail-section,.profile-v2 .preparation-reference>.detail-section,.profile-v2 .research-reference>.detail-section{margin-bottom:28px}.profile-v2 .uses-group{padding-top:22px}.profile-v2 .uses-group>h3>span{margin:4px 0 0;display:block}.profile-v2 .use-answer h4{font-size:17px}.profile-v2 .use-answer p{font-size:14px}.profile-v2 .use-answer>div{gap:8px}.profile-v2 .evidence-verdict{font-size:26px}.profile-v2 .overview-facts{margin-bottom:28px;padding:4px 21px}.profile-v2 .overview-facts a{padding:22px 0;display:block}.profile-v2 .overview-facts strong,.profile-v2 .overview-facts small{margin-top:9px;display:block}.profile-v2 .overview-facts strong{font-size:18px}.profile-fold{margin-bottom:28px;padding:0 21px}.profile-fold>summary{padding-block:22px;font-size:16px}.profile-fold>summary>span{margin:6px 0 0;display:block}.profile-v2 .cycle-card dl>div{grid-template-columns:80px 1fr}.profile-v2 .pk-facts strong{font-size:24px}.profile-v2 .pk-chart{max-width:100%}.profile-v2 .protocol-table{min-width:920px}.profile-v2 [data-view=compact] .protocol-table{min-width:0}.profile-v2 [data-view=compact] .protocol-table tbody{margin-bottom:20px;padding:22px 17px}.profile-v2 [data-view=compact] .protocol-table tbody>tr:first-child{gap:22px 15px}.profile-v2 .protocol-toolbar{margin-top:20px}.profile-v2 .table-filters{gap:6px;display:flex}.profile-v2 .table-filters button{padding:9px 10px;font-size:11px}.profile-v2 .source-filters{gap:6px}.profile-v2 .reference-tools{flex-wrap:wrap;gap:15px}.vial-calculator .form-row{display:block}.vial-calculator .field-label>span{font-size:11px;display:inline}.vial-calculator .form-input,.vial-calculator .input-unit input{font-size:16px}.vial-calculator .calc-output .result-panel{padding:24px 20px}.vial-calculator .result-main{display:block}.vial-calculator .result-main>span{margin-top:6px;display:block}.vial-calculator .increment-callout{gap:8px}.vial-calculator .increment-callout strong{font-size:22px}.vial-calculator .math-breakdown>div{font-size:12px}.vial-calculator .calc-form-actions{flex-wrap:wrap;gap:18px}.source-dialog{max-height:90dvh;padding:20px 22px}.source-dialog h2{font-size:21px}}.profile-v2 .use-answer>div>h4{flex:1;min-width:180px}.profile-v2 .dose-stage{color:#6b7e95;margin-top:7px;font-size:11px;font-weight:500;line-height:1.7;display:block}.profile-v2 .protocol-source-context{margin-bottom:16px;padding-block:10px}.profile-v2 .table-filters{background:0 0;border:0;padding:0}@media (width<=720px){.profile-v2 .protocol-toolbar{align-items:center;gap:10px;margin-top:14px;margin-bottom:20px;display:flex}.profile-v2 .protocol-row-count{padding:0}.profile-v2 .table-filters button{padding-inline:13px;font-size:12px}.profile-v2 .protocol-view-switch{margin-bottom:22px}.profile-v2 .use-answer>div{flex-wrap:nowrap;align-items:flex-start}.profile-v2 .use-answer>div>h4{min-width:0}.profile-v2 .use-answer .source-refs{flex-shrink:0}}.profile-v2 [id]{scroll-margin-top:calc(var(--site-header-height) + var(--profile-nav-height) + 20px)}.profile-v2 [data-profile-section]+[data-profile-section]{margin-top:48px}.profile-jumpnav{height:auto}.profile-jumpnav a{justify-content:center}.profile-v2 .overview-facts{height:auto;display:block}@media (width<=360px){.profile-jumpnav{padding-inline:6px}.profile-jumpnav a{padding-inline:4px}}@media (width<=720px){.profile-v2 [data-profile-section]+[data-profile-section]{margin-top:36px}}