.community-poll[data-astro-cid-2tsrdfht]{padding-bottom:0}.community-poll[data-astro-cid-2tsrdfht][open]{padding-bottom:24px}.poll-context[data-astro-cid-2tsrdfht]{color:#7d6b48;max-width:800px;margin:0 0 23px;font-size:13px;line-height:1.85}.poll-topic[data-astro-cid-2tsrdfht]{color:#62778e;align-items:center;gap:20px;margin-bottom:27px;font-size:13px;display:flex}.poll-topic[data-astro-cid-2tsrdfht] select[data-astro-cid-2tsrdfht]{min-width:230px;max-width:100%;font:inherit;color:#385675;background:#fff;border:1px solid #d8e2ed;border-radius:7px;padding:12px;font-size:14px}.community-poll[data-astro-cid-2tsrdfht] h3[data-astro-cid-2tsrdfht]{color:#344f70;margin:0 0 24px;font-size:19px}.poll-bars[data-astro-cid-2tsrdfht]{max-width:720px}.poll-answer[data-astro-cid-2tsrdfht]{margin:19px 0}.poll-answer[data-astro-cid-2tsrdfht]>div[data-astro-cid-2tsrdfht]:first-child{color:#536981;justify-content:space-between;gap:24px;font-size:13px;line-height:1.7;display:flex}.poll-answer[data-astro-cid-2tsrdfht] strong[data-astro-cid-2tsrdfht]{color:#87692f}.poll-track[data-astro-cid-2tsrdfht]{background:#f2eee6;border-radius:8px;height:7px;margin-top:9px;overflow:hidden}.poll-track[data-astro-cid-2tsrdfht] i[data-astro-cid-2tsrdfht]{background:#bf9b5c;border-radius:8px;height:100%;display:block}.poll-caveat[data-astro-cid-2tsrdfht]{color:#8090a3;margin-top:18px;font-size:11px;line-height:1.8}.poll-footer[data-astro-cid-2tsrdfht]{color:#8390a1;border-top:1px solid #e2e8ef;justify-content:space-between;gap:15px;margin-top:23px;padding-top:20px;font-size:11px;display:flex}.poll-footer[data-astro-cid-2tsrdfht] a[data-astro-cid-2tsrdfht]{color:#3769a7}.community-poll[data-astro-cid-2tsrdfht] .quiet-details[data-astro-cid-2tsrdfht] li[data-astro-cid-2tsrdfht]{margin:10px 0;font-size:12px;line-height:1.85}.community-poll[data-astro-cid-2tsrdfht] .quiet-details[data-astro-cid-2tsrdfht] ul[data-astro-cid-2tsrdfht]{padding-left:18px}@media (width<=600px){.poll-topic[data-astro-cid-2tsrdfht]{display:block}.poll-topic[data-astro-cid-2tsrdfht] select[data-astro-cid-2tsrdfht]{width:100%;margin-top:10px;display:block}}.detail-page .use-lead{color:#344b68;max-width:960px;margin:0 0 26px;font-size:17px;line-height:1.8}.detail-page .use-column{padding:23px}.detail-page .use-column-heading{margin-bottom:15px}.detail-page .use-item{padding:12px 0}.detail-page .use-item h4{font-size:16px}.detail-page .use-item p{margin-top:5px}.detail-page .use-columns{align-items:start}.detail-page .use-status{margin-top:14px}.detail-page .overview-grid{grid-template-columns:1.1fr 1fr;gap:28px;display:grid}.detail-page .overview-grid>.detail-section{height:100%}.detail-page .detail-section-heading .section-action{color:#39699e;white-space:nowrap;font-size:12px;font-weight:600}.detail-page .evidence-summary{--section-accent:#578eae;--section-surface:#f3f9fc}.detail-page .safety-summary{--section-accent:#d28a75;--section-surface:#fff8f4}.detail-page .evidence-at-glance{grid-template-columns:1.6fr 1fr 1fr;align-items:start;gap:20px;margin-bottom:20px;display:grid}.detail-page .evidence-at-glance>div{min-width:0}.detail-page .evidence-at-glance strong{color:#294d71;letter-spacing:-.5px;font-size:26px;line-height:1.3;display:block}.detail-page .evidence-at-glance>div:first-child strong{margin-top:7px;font-size:21px}.detail-page .evidence-at-glance span{color:#677d95;font-size:11px;line-height:1.65;display:block}.detail-page .evidence-context{color:#445c75;font-size:13px;line-height:1.8}.detail-page .subtle-note{color:#738196;margin-top:14px;font-size:11px;line-height:1.8}.detail-page .safety-preview{gap:18px;display:grid}.detail-page .safety-preview h3{color:#825344;font-size:15px;line-height:1.6}.detail-page .safety-preview p{color:#645b58;margin-top:4px;font-size:12px;line-height:1.8}.detail-page .practical-facts{grid-template-columns:repeat(3,minmax(0,1fr));gap:18px;display:grid}.detail-page .practical-facts a{background:#f9fcfd;border:1px solid #dbe5ed;border-radius:12px;flex-direction:column;align-items:start;min-width:0;padding:22px 24px;display:flex}.detail-page .practical-facts a:nth-child(2){background:#fffdf7;border-color:#eae1cc}.detail-page .practical-facts a:nth-child(3){background:#fbfaff;border-color:#e1ddef}.detail-page .practical-facts span{color:#61748c;font-size:11px}.detail-page .practical-facts strong{color:#2f4e70;margin:8px 0;font-size:19px;line-height:1.5}.detail-page .practical-facts small{color:#718197;margin-top:auto;font-size:10px}.detail-page .protocol-view-switch{display:none}.detail-page .cycle-guide{border-top:1px solid #dce6ef;margin-top:30px;padding-top:27px;scroll-margin-top:100px}.detail-page .subsection-heading{flex-wrap:wrap;align-items:center;gap:10px;display:flex}.detail-page .subsection-heading h3{letter-spacing:-.3px;color:#34526f;font-size:17px;font-weight:650}.detail-page .source-type{white-space:nowrap;border-radius:5px;padding:4px 7px;font-size:10px;line-height:1.5}.detail-page .reference-type{color:#8c6c32;background:#fbf0d9}.detail-page .cycle-grid{grid-template-columns:repeat(auto-fit,minmax(240px,1fr));gap:16px;margin-top:18px;display:grid}.detail-page .cycle-card{background:#fbfcff;border:1px solid #e0e7f0;border-radius:10px;min-width:0;padding:20px}.detail-page .cycle-card h4{color:#426386;margin-bottom:17px;font-size:13px;font-weight:650}.detail-page .cycle-card dl>div{border-bottom:1px solid #e5eaf2;grid-template-columns:78px 1fr;gap:15px;padding:9px 0;display:grid}.detail-page .cycle-card dt{color:#718197;font-size:11px}.detail-page .cycle-card dd{color:#3d536e;margin:0;font-size:12px;line-height:1.8}.detail-page .cycle-card details{color:#5d728d;margin-top:17px;font-size:11px;line-height:1.8}.detail-page .cycle-card summary{cursor:pointer;color:#4c6d96;font-weight:600}.detail-page .cycle-card details p{margin-top:10px}.detail-page .storage-section{--section-accent:#4c9990;--section-surface:#f3faf7}.detail-page .storage-grid{grid-template-columns:repeat(auto-fit,minmax(240px,1fr));gap:14px;margin-top:18px;display:grid}.detail-page .storage-grid article{background:#f8fcfa;border:1px solid #dcebe4;border-radius:9px;padding:20px}.detail-page .storage-grid span{color:#458271;font-size:11px;font-weight:650}.detail-page .storage-grid p{color:#355a4e;margin-top:9px;font-size:16px;line-height:1.8}.detail-page .context-note{color:#65778c;background:#f7f9fc;border-left:3px solid #c4d1df;margin-top:22px;padding:15px 18px;font-size:12px;line-height:1.8}.detail-page .label-storage{margin-bottom:28px}.detail-page .label-storage>h3{color:#2d6b5c;margin-bottom:16px;font-size:17px}.detail-page .label-storage article{border-bottom:1px solid #e0e9e5;padding:16px 0}.detail-page .label-storage h4{color:#3c6259;font-size:14px}.detail-page .label-storage p{color:#546f66;margin-top:6px;font-size:12px;line-height:1.8}.detail-page .reference-cautions{border-top:1px solid #ecdcd8;margin-top:25px;padding-top:24px}.detail-page .reference-cautions article{margin:20px 0}.detail-page .reference-cautions h4{color:#79554e;font-size:14px}.detail-page .reference-cautions p{color:#6b6667;margin-top:6px;font-size:13px;line-height:1.8}.detail-page .safety-detail-grid>.detail-section{width:100%}.detail-page .interaction-section{--section-accent:#c09b56;--section-surface:#fffbf3}.detail-page .section-count{color:#7e8a9b;white-space:nowrap;font-size:11px}.detail-page .interaction-search{margin-top:22px;display:block}.detail-page .interaction-search input{width:100%;font:inherit;color:#354e6c;background:#fff;border:1px solid #dce3ed;border-radius:8px;padding:14px 16px;font-size:14px}.detail-page .interaction-search input:focus{outline-offset:2px;outline:2px solid #9ebde4}.detail-page .interaction-filters{flex-wrap:wrap;gap:7px;margin:16px 0 20px;display:flex}.detail-page .interaction-filters button,.detail-page .protocol-view-switch button{color:#64748b;background:#fff;border:1px solid #e0e6ef;border-radius:7px;padding:9px 13px;font-size:12px}.detail-page .interaction-filters button[aria-pressed=true],.detail-page .protocol-view-switch button[aria-pressed=true]{color:#3e659e;background:#edf3fc;border-color:#bed0eb}.detail-page .interaction-rows{grid-template-columns:1fr 1fr;gap:14px;display:grid}.detail-page .interaction-row{background:#fbfcfe;border:1px solid #e1e6ed;border-radius:10px;min-width:0;padding:20px}.detail-page .interaction-row[hidden]{display:none}.detail-page .interaction-caution{background:#fffcf6;border-color:#eadfc7}.detail-page .interaction-row-title{flex-wrap:wrap;justify-content:space-between;align-items:start;gap:12px;display:flex}.detail-page .interaction-row h3{color:#3d5472;letter-spacing:-.2px;font-size:15px;line-height:1.6}.detail-page .interaction-row-title>span{color:#6c7b90;background:#eef2f7;border-radius:5px;padding:4px 7px;font-size:10px;line-height:1.5}.detail-page .interaction-caution .interaction-row-title>span{color:#8d6b2e;background:#f9edcf}.detail-page .interaction-row p{color:#586b83;margin-top:11px;font-size:13px;line-height:1.8}.detail-page .interaction-row>small{color:#8995a5;margin-top:12px;font-size:10px;line-height:1.7;display:block}.detail-page .source-corrections{background:#fffaf0;border:1px solid #eddfbd;border-radius:9px;margin-bottom:20px;padding:18px 21px}.detail-page .source-corrections h3{color:#8e6c35;margin-bottom:8px;font-size:14px}.detail-page .source-corrections p{color:#796d55;margin-top:8px;font-size:12px;line-height:1.8}.detail-page .research-updates{margin-top:26px}.detail-page .research-updates>h3{color:#3b697c;font-size:18px}.detail-page .research-updates h4{font-size:14px;line-height:1.8}.detail-page .research-updates details>small{color:#788a9d;margin-top:12px;font-size:11px;display:block}.detail-page .expectations-section{--section-accent:#768ab9;--section-surface:#f7f8fd}.detail-page .expectation-columns{grid-template-columns:1fr 1fr;gap:28px;display:grid}.detail-page .expectation-columns>div{min-width:0}.detail-page .expectation-columns h3{color:#3f5882;margin-bottom:14px;font-size:18px}.detail-page .expectation-columns article{border-bottom:1px solid #e4e8f0;padding:18px 0}.detail-page .expectation-columns h4{color:#50617d;font-size:14px;line-height:1.7}.detail-page .expectation-columns p{color:#65758d;margin-top:6px;font-size:13px;line-height:1.9}.detail-page .reported-expectations{background:#fffcf5;border:1px solid #eae0cd;border-radius:10px;padding:22px}.detail-page .reference-preparation article{border-bottom:1px solid #e1e8ec;padding:17px 0}.detail-page .reference-preparation h4{color:#4a6b7e;margin-bottom:12px;font-size:13px}.detail-page .reference-preparation dl>div{color:#66798b;grid-template-columns:110px 1fr;gap:16px;margin-top:8px;font-size:12px;line-height:1.8;display:grid}.detail-page .reference-preparation dd{margin:0}.detail-page .quality-indicators{flex-wrap:wrap;gap:8px;margin:18px 0;display:flex}.detail-page .quality-indicators span{color:#69798e;background:#f3f6fa;border:1px solid #e1e8f0;border-radius:6px;padding:7px 10px;font-size:11px}.detail-page .section-nav-links{scrollbar-width:none}.detail-page .section-nav-links::-webkit-scrollbar{display:none}.detail-page.detail-page .section-nav .section-nav-links a{padding-inline:11px;font-size:12px}.detail-page .science-grid.kinetics-grid{align-items:start}@media (width<=1000px){.detail-page .overview-grid{grid-template-columns:1fr}.detail-page .interaction-rows{grid-template-columns:1fr 1fr}.detail-page .practical-facts a{padding:19px}.detail-page .practical-facts strong{font-size:17px}}@media (width<=720px){.detail-page.detail-page.wrap{padding-inline:16px}.detail-page.detail-page .breadcrumb{padding-block:20px}.detail-page .detail-header h1{font-size:36px}.detail-page .profile-sections{gap:24px}.detail-page .profile-meta{margin-top:15px}.detail-page .section-nav{gap:0;height:56px;min-height:56px;margin:22px 0;padding:6px;top:6px;overflow:hidden}.detail-page .section-nav-links{gap:3px;display:flex;overflow-x:auto}.detail-page .section-nav .section-nav-links a{align-items:center;min-height:42px;padding:11px 12px;font-size:12px;display:flex}.detail-page .section-select-label{display:none}.detail-page .use-lead{margin-bottom:20px;font-size:15px;line-height:1.8}.detail-page .use-columns{gap:17px}.detail-page .community-uses{order:0}.detail-page .clinical-uses{order:1}.detail-page .use-column{padding:20px 17px}.detail-page .use-column h3{font-size:18px}.detail-page .use-column-heading{margin-bottom:12px}.detail-page .use-item h4{font-size:16px}.detail-page .use-item p{font-size:13px}.detail-page .community-use-note{padding-top:9px;font-size:11px;line-height:1.7}.detail-page .use-next-links{grid-template-columns:1fr;gap:8px;margin-top:20px;padding-top:18px;display:grid}.detail-page .use-next-links a{min-width:0;min-height:44px}.detail-page .detail-section>.detail-section-heading{min-height:78px;margin-bottom:21px;padding-block:18px}.detail-page .detail-section h2{font-size:21px}.detail-page .detail-section-heading .section-action{font-size:11px}.detail-page .evidence-at-glance{grid-template-columns:1.4fr 1fr 1fr;gap:14px}.detail-page .evidence-at-glance strong{font-size:24px}.detail-page .evidence-at-glance>div:first-child strong{font-size:18px}.detail-page .evidence-at-glance span{font-size:10px}.detail-page .evidence-context{font-size:13px}.detail-page .subtle-note{font-size:11px}.detail-page .safety-preview p{font-size:13px}.detail-page .practical-facts{grid-template-columns:1fr;gap:10px}.detail-page .practical-facts a{grid-template-columns:1fr 1.5fr;align-items:center;gap:4px 15px;padding:17px 18px;display:grid}.detail-page .practical-facts strong{text-align:right;margin:0;font-size:16px;line-height:1.6}.detail-page .practical-facts small{text-align:right;grid-column:1/-1}.detail-page .cycle-grid{grid-template-columns:1fr;gap:13px}.detail-page .cycle-card{padding:18px}.detail-page .cycle-card dl>div{grid-template-columns:65px 1fr;gap:15px}.detail-page .cycle-guide{padding-top:23px;scroll-margin-top:88px}.detail-page .interaction-rows{grid-template-columns:1fr}.detail-page .interaction-row{padding:19px}.detail-page .interaction-row h3{font-size:16px}.detail-page .interaction-filters button{min-height:42px;padding:10px 12px;font-size:11px}.detail-page .interaction-row p{font-size:13px}.detail-page .interaction-search input{min-height:46px;font-size:14px}.detail-page .expectation-columns{grid-template-columns:1fr;gap:22px}.detail-page .reported-expectations{padding:19px}.detail-page .storage-grid{grid-template-columns:1fr}.detail-page .storage-grid p{font-size:15px}.detail-page .storage-grid article{padding:19px}.detail-page .reference-preparation dl>div{grid-template-columns:1fr;gap:4px}.detail-page .context-note{padding:14px 16px;font-size:11px}.detail-page .detail-section{scroll-margin-top:88px}.detail-page .protocol-view-switch{gap:6px;margin:0 0 17px;display:flex}.detail-page .protocol-view-switch button{min-height:42px}.detail-page .protocol-toolbar{display:block}.detail-page .protocol-row-count{text-align:right;padding-top:10px;display:block}.detail-page .table-filters button{min-height:42px;font-size:11px}.detail-page .route-filters{gap:6px}.detail-page .route-filters button{min-height:38px;padding:8px 10px;font-size:11px}.detail-page [data-view=compact] .table-scroll-hint{display:none}.detail-page [data-view=compact] .protocol-scroll{outline-offset:5px;overflow:visible}.detail-page [data-view=compact] .protocol-table{border:0;width:100%;min-width:0;display:block}.detail-page [data-view=compact] .protocol-table thead{clip:rect(0,0,0,0);white-space:nowrap;border:0;width:1px;height:1px;margin:-1px;padding:0;position:absolute;overflow:hidden}.detail-page [data-view=compact] .protocol-table tbody{background:#fafdff;border:1px solid #dce6f2;border-left:3px solid #5c86c9;border-radius:10px;margin-bottom:15px;padding:18px 16px;display:block}.detail-page [data-view=compact] .protocol-table tbody[data-protocol-group=community]{background:#fffdf8;border-left-color:#c6a161}.detail-page [data-view=compact] .protocol-table tbody[hidden]{display:none}.detail-page [data-view=compact] .protocol-table tbody>tr:first-child{grid-template-columns:1.15fr 1fr;gap:16px 14px;display:grid}.detail-page [data-view=compact] .protocol-table tbody th,.detail-page [data-view=compact] .protocol-table tbody td{border:0;min-width:0;padding:0;line-height:1.8;display:block;position:static;box-shadow:none!important;background:0 0!important;width:auto!important}.detail-page [data-view=compact] .protocol-table .protocol-goal{grid-area:1/1/2/2}.detail-page [data-view=compact] .protocol-table .protocol-route{text-align:right;grid-area:1/2/2/3}.detail-page [data-view=compact] .protocol-route>small{display:none}.detail-page [data-view=compact] .protocol-goal strong{margin-bottom:7px;font-size:14px;line-height:1.7}.detail-page [data-view=compact] .protocol-table .protocol-dose{color:#244e83;overflow-wrap:anywhere;grid-area:2/1/3/2;font-size:20px;font-weight:750;line-height:1.6}.detail-page [data-view=compact] .protocol-table .protocol-frequency{color:#3e5672;grid-area:2/2/3/3;font-size:14px}.detail-page [data-view=compact] .protocol-table .protocol-duration{color:#64758b;grid-area:3/1/4/2;font-size:12px}.detail-page [data-view=compact] .protocol-table .protocol-source{text-align:right;grid-area:3/2/4/3;align-self:end}.detail-page [data-view=compact] [data-label]:before{content:attr(data-label);color:#8290a2;margin-bottom:6px;font-size:10px;font-weight:500;line-height:1.5;display:block}.detail-page [data-view=compact] .protocol-source .source-ref{margin-right:4px}.detail-page [data-view=compact] .protocol-details-button{min-height:36px;padding:5px 0;font-size:12px}.detail-page [data-view=compact] .protocol-context:not([hidden]){border-top:1px solid #e5e9ef;margin-top:18px;padding-top:17px;display:block}.detail-page [data-view=compact] .protocol-context td>div{margin-top:12px;display:block}.detail-page [data-view=compact] .protocol-context td strong{font-size:11px}.detail-page [data-view=compact] .protocol-context td p{margin-top:4px;font-size:12px;line-height:1.8}.detail-page .protocol-origin{font-size:9px}}.detail-page .protocol-source-context{background:#fffaf0;border:1px solid #e8d9b8;border-left:3px solid #b58d47;border-radius:8px;margin-bottom:22px;padding:15px 18px}.detail-page .protocol-source-context p{color:#736343;font-size:12px;line-height:1.8}.detail-page .protocol-source-context p+p{margin-top:9px}.detail-page .quality-indicators span{flex-direction:column;gap:4px;display:flex}.detail-page .quality-indicators small{color:#8a97a5;font-size:9px}.detail-page .quality-indicators .reported-concern{color:#94604f;background:#fff7f4;border-color:#e6cfc8}.detail-page .quality-indicators .reported-concern small{color:#ad7c6b}.detail-page .use-disclosure summary{cursor:pointer;justify-content:space-between;align-items:center;gap:15px;list-style:none;display:flex}.detail-page .use-disclosure summary::-webkit-details-marker{display:none}.detail-page .use-disclosure summary>span{color:#a88c55;font-size:19px;line-height:1}.detail-page .use-disclosure[open] summary>span{transform:rotate(45deg)}.detail-page .community-uses .use-disclosure{padding-block:14px}.detail-page .community-uses .use-column-heading+.use-disclosure{padding-top:0}.profile-v2 .compact-chain{background:#fff;margin:18px 0 12px;padding:0}.compact-chain ol{flex-wrap:wrap;gap:9px 0;max-width:660px;margin:0;padding:0;list-style:none;display:flex}.compact-chain li{align-items:center;margin:0;padding:0;display:flex;position:relative}.compact-chain li:not(:last-child):after{content:"";background:#c8badf;width:8px;height:1px}.compact-chain li>span{letter-spacing:-.2px;color:#62498b;background:#f5f1fb;border:1px solid #d9cee9;border-radius:50%;place-items:center;width:28px;height:28px;font-size:9px;font-weight:650;line-height:1;display:grid}.compact-chain .acid-1>span{color:#3b766a;background:#eef8f5;border-color:#c9e4e0}.compact-chain .acid-2>span{color:#476f9e;background:#f0f5fc;border-color:#d3e0f1}.compact-chain .modified-acid>span{color:#61408b;background:#f3edf9;border-color:#b5a1d2;width:34px;font-size:7px}.compact-chain p{color:#756880;margin-top:12px;font-size:10px}.profile-v2 #molecular .molecule-stats{gap:24px;margin-bottom:0}.profile-v2 #molecular .molecule-stats strong{font-size:17px;line-height:1.6}.profile-v2 #molecular .sequence-section{margin-top:18px;padding-top:18px}.profile-v2 #molecular .sequence-heading h3{font-size:14px}.profile-v2 #molecular .sequence-note{max-width:760px;margin:10px 0;font-size:11px}.profile-v2 #molecular .quiet-details{padding-block:13px}.profile-v2 #molecular .sequence-text,.profile-v2 #molecular .sequence-gap{background:#fff}.profile-v2 #molecular .molecule-formula{margin-block:16px}.profile-v2 .pk-duration-summary{border-block:1px solid #e3eaf1;max-width:600px;margin-top:20px;padding:18px 0}.profile-v2 .pk-duration-summary strong{color:#286e63;font-size:17px;line-height:1.5;display:block}.profile-v2 .pk-duration-summary p{color:#5e7186;margin-top:5px;font-size:12px;line-height:1.7}.profile-v2 .pk-interpretation{background:#fff}.profile-v2 .storage-section h3{letter-spacing:0;color:#31546a;font-size:16px}.profile-v2 .storage-help{color:#607286;max-width:760px;margin:8px 0 18px;font-size:12px;line-height:1.8}.profile-v2 .storage-limit{border:1px solid #d7e5e3;background:#fff;border-left:3px solid #58a28e;border-radius:9px;margin:12px 0;padding:20px 22px}.storage-limit>div{flex-wrap:wrap;align-items:center;gap:8px;margin-bottom:12px;display:flex}.profile-v2 .storage-limit h4{color:#344b62;font-size:14px;line-height:1.5}.profile-v2 .storage-limit>strong{letter-spacing:-.4px;color:#254e59;font-size:23px;line-height:1.4;display:block}.profile-v2 .storage-limit>span{color:#4a6377;margin-top:6px;font-size:13px;font-weight:550;display:block}.profile-v2 .storage-limit>p,.profile-v2 .storage-unknown p,.profile-v2 .storage-label-note p{color:#637185;max-width:780px;margin-top:10px;font-size:12px;line-height:1.85}.profile-v2 .reported-limit{border-color:#e7dfd0 #e7dfd0 #e7dfd0 #bf9b60}.profile-v2 .reported-limit>strong{color:#806332}.storage-evidence{color:#896a31;font-size:10px;font-weight:600}.profile-v2 .storage-research:not(:first-child),.profile-v2 .storage-ready-products{margin-top:28px}.profile-v2 .storage-research:nth-child(2){margin-top:0}.profile-v2 .storage-unknown{padding:18px 0 8px}.profile-v2 .storage-unknown>strong{color:#3e536b;font-size:21px;font-weight:650;line-height:1.5}.profile-v2 .storage-label-note{border-bottom:1px solid #e3eaf1;padding:17px 0}.profile-v2 .storage-label-note h4{color:#344b62;font-size:14px}.profile-v2 .storage-source-details{margin-top:20px}.profile-v2 .storage-grid article{background:#fff}.profile-v2 .storage-section .context-note{background:#fff;border:0;padding:0;font-size:11px;line-height:1.8}@media (width<=720px){.profile-v2 #molecular .molecule-stats{display:block}.profile-v2 #molecular .molecule-stats>div+div{margin-top:14px}.profile-v2 .storage-limit{padding:18px}.profile-v2 .storage-limit>strong{font-size:22px}.profile-v2 .pk-duration-summary strong{font-size:16px}}.profile-v2 #molecular .sequence-section{border:0;margin:0;padding:0}.profile-v2 #molecular .molecule-stats{border-top:1px solid #e6e4ec;margin-top:20px;padding-top:18px}.profile-v2 #molecular .molecule-details{margin-top:18px;padding-bottom:0}.profile-v2 #molecular .compact-chain .source-ref{vertical-align:middle;margin-left:8px}.profile-page{color:#26384f;background:#fff}.profile-hero{--profile-accent:#4479c5;background:radial-gradient(at 8% 0,#dfeefa 0,#0000 55%),radial-gradient(at 92% 30%,#e8e5f6 0,#0000 58%),#f1f5fa;padding:24px 28px 0;display:block}.profile-hero[data-category=Recovery]{--profile-accent:#328878}.profile-hero[data-category="Mind & sleep"],.profile-hero[data-category=Longevity]{--profile-accent:#8364b1}.profile-hero[data-category="Skin & hair"]{--profile-accent:#b97091}.hero-inner{background:#fff;border-radius:20px 20px 0 0;width:100%;max-width:1144px;margin:auto;padding:24px 36px 26px;box-shadow:0 -2px 35px #3b557506}.profile-hero .breadcrumb{color:#65748a;gap:10px;margin:0 0 23px;padding:0;font-size:11px}.profile-hero .breadcrumb a{color:#61738b;transition:color .16s}.profile-hero .breadcrumb a:hover{color:#2765b5}.hero-heading{justify-content:space-between;align-items:center;gap:32px;display:flex}.hero-heading>div:first-child{min-width:0}.profile-hero .profile-labels{align-items:center;gap:10px;margin:0 0 9px;display:flex}.hero-category{color:var(--profile-accent);align-items:center;gap:7px;font-size:11px;font-weight:650;display:flex}.hero-category i{background:var(--profile-accent);border-radius:50%;width:6px;height:6px}.profile-hero .kind-label{color:#6a788b;background:#fff;border:1px solid #e2e8f0;border-radius:5px;padding:2px 6px;font-size:10px}.profile-hero h1{letter-spacing:-1.9px;color:#1d2d43;overflow-wrap:anywhere;margin:0;font-size:48px;font-weight:750;line-height:1.12}.hero-tagline{color:#68758a;max-width:780px;margin-top:10px;font-size:15px;line-height:1.7}.profile-hero .detail-actions{flex-shrink:0;gap:10px;margin:0;display:flex}.hero-icon-action{color:#63778f;cursor:pointer;background:#fff;border:1px solid #e0e7ef;border-radius:9px;justify-content:center;align-items:center;gap:7px;min-height:40px;padding:9px 12px;font-size:12px;transition:color .16s,border-color .16s,box-shadow .16s;display:inline-flex}.hero-icon-action:hover{color:#2f66ae;border-color:#b8cde8;box-shadow:0 3px 10px #2d51740b}.hero-icon-action[aria-pressed=true]{color:#2861b0;border-color:#a8c4e6}.hero-use-summary{flex-wrap:wrap;gap:14px 38px;margin-top:23px;display:flex}.hero-use-summary>div{flex-wrap:wrap;align-items:baseline;gap:8px;display:flex}.hero-use-summary>div>span{color:#3d6e97;font-size:11px;font-weight:600}.hero-use-summary strong{color:#30435b;font-size:14px;font-weight:600;line-height:1.7}.hero-use-summary .hero-community>span{color:#886629}.profile-hero .source-ref{color:#65748a;text-underline-offset:3px;vertical-align:baseline;background:#fff;border:0;min-width:16px;height:18px;margin:0;padding:0;font-size:10px;text-decoration:underline #c9d4e2}.profile-hero .source-ref:hover{color:#245fae}.hero-status{color:#65748a;align-items:flex-start;gap:7px;max-width:890px;margin:15px 0 0;font-size:11px;line-height:1.7;display:flex}.hero-status svg{color:#8597ab;flex-shrink:0;margin-top:2px}.hero-facts{border-top:1px solid #e8edf3;grid-template-columns:repeat(4,minmax(0,1fr));gap:26px;margin-top:24px;padding-top:23px;display:grid}.hero-facts a{border-radius:6px;flex-direction:column;align-items:flex-start;gap:7px;min-width:0;display:flex}.hero-facts a>span{color:#65748a;font-size:11px;font-weight:500}.hero-facts strong{letter-spacing:-.5px;color:#324960;font-size:20px;font-weight:650;line-height:1.35;transition:color .16s}.hero-facts small{color:#65748a;font-size:10px;line-height:1.6}.hero-facts small>span{color:var(--profile-accent);transition:transform .16s;display:inline-block}.hero-facts a:hover strong{color:var(--profile-accent)}.hero-facts a:hover small>span{transform:translate(2px,-2px)}.detail-page.profile-v2.profile-v3.wrap{max-width:1144px;padding:0 36px 60px}.profile-v2.profile-v3 .profile-jumpnav{background:#fffffff5;border-color:#e7ecf2;align-items:stretch;gap:22px;min-height:61px;margin:0 0 42px;padding:0}.profile-v2.profile-v3 .profile-jumpnav a{color:#6b7a8c;border-bottom-width:2px;border-radius:0;flex:none;padding:21px 2px 18px;font-size:12px;font-weight:550}.profile-v2.profile-v3 .profile-jumpnav a:hover{color:#2862a8;background:0 0}.profile-v2.profile-v3 .profile-jumpnav a[aria-current=location]{color:#235ea8;background:0 0;border-bottom-color:#3a77c6}.profile-v2.profile-v3 .profile-jumpnav .profile-sources-link{color:#587294;margin-left:auto}.profile-sources-link>span{margin-left:4px;font-size:11px}.profile-v2.profile-v3 .profile-overview-layout{grid-template-columns:minmax(0,1fr) 320px;align-items:start;gap:66px;margin-bottom:54px;display:grid}.profile-v2.profile-v3 .detail-section{box-shadow:none;background:#fff;border:0;border-radius:0;padding:0;overflow:visible}.profile-v2.profile-v3 [data-profile-section]>.detail-section,.profile-v2.profile-v3 .preparation-reference>.detail-section{margin:0 0 56px}.profile-v2.profile-v3 .profile-overview-copy>.detail-section{margin:0 0 38px}.profile-v2.profile-v3 .profile-overview-copy>.detail-section:last-child{margin-bottom:0}.profile-v2.profile-v3 .detail-section>.detail-section-heading{background:0 0;border:0;align-items:baseline;gap:16px;min-height:0;margin:0 0 22px;padding:0}.profile-v2.profile-v3 .detail-section h2{letter-spacing:-.8px;color:#24374e;font-size:27px;font-weight:680;line-height:1.3}.profile-v2.profile-v3 .detail-section-heading .section-action{font-size:11px;line-height:1.6}.profile-v2.profile-v3 .overview-lead{color:#607084;margin:0 0 26px;font-size:14px;line-height:1.85}.profile-v2.profile-v3 .uses-group{border:0;padding:0}.profile-v2.profile-v3 .uses-group+.uses-group{margin-top:24px}.profile-v2.profile-v3 .uses-group>h3{color:#477799;margin:0 0 9px;font-size:11px;font-weight:650}.profile-v2.profile-v3 .uses-group>h3:before{content:"";background:#709cbb;border-radius:50%;width:5px;height:5px;margin:0 7px 2px 0;display:inline-block}.profile-v2.profile-v3 .reported-uses>h3{color:#886629}.profile-v2.profile-v3 .reported-uses>h3:before{background:#bd9b61}.profile-v2.profile-v3 .uses-group>h3>span{color:#65748a;margin-left:7px;font-size:10px}.profile-v2.profile-v3 .use-answer{border:0;padding:10px 0}.profile-v2.profile-v3 .use-answer h4{color:#33485f;letter-spacing:-.15px;font-size:15px;font-weight:600;line-height:1.5}.profile-v2.profile-v3 .use-answer>div>h4{min-width:0}.profile-v2.profile-v3 .use-answer>div{align-items:baseline;gap:5px}.profile-v2.profile-v3 .use-answer p{color:#6a788b;margin-top:5px;font-size:13px;line-height:1.8}.profile-v2.profile-v3 .use-disclaimer{color:#65748a;margin-top:10px;font-size:10px;line-height:1.7}.profile-v2.profile-v3 .use-answer .source-ref{color:#74869e;text-underline-offset:3px;background:#fff;border:0;min-width:18px;min-height:21px;font-size:10px;text-decoration:underline #c4d1e1}.profile-v2.profile-v3 #evidence-summary{border-top:1px solid #edf0f4;padding-top:25px}.profile-v2.profile-v3 #evidence-summary h2,.profile-v2.profile-v3 #safety-summary h2{letter-spacing:-.35px;font-size:20px}.profile-v2.profile-v3 #evidence-summary .detail-section-heading,.profile-v2.profile-v3 #safety-summary .detail-section-heading{margin-bottom:12px}.profile-v2.profile-v3 .evidence-context{color:#5f7085;font-size:13px;line-height:1.85}.evidence-coverage{margin-top:10px}.evidence-coverage p{color:#65748a;font-size:11px;line-height:1.8}.evidence-coverage a{color:#6581a1;margin-top:9px;font-size:11px;display:inline-block}.profile-v2.profile-v3 #safety-summary{border-left:2px solid #dcc395;padding-left:17px}.profile-v2.profile-v3 .safety-preview h3{color:#876844;font-size:14px;line-height:1.7}.profile-v2.profile-v3 .safety-preview p{color:#6e798a;margin-top:5px;font-size:13px;line-height:1.8}.profile-v2.profile-v3 #safety-summary>.subtle-note{display:none}.profile-quick-guide{top:calc(var(--site-header-height) + var(--profile-nav-height) + 22px);scroll-margin-top:calc(var(--site-header-height) + var(--profile-nav-height) + 22px);background:#fff;border:1px solid #e0e7ef;border-radius:15px;padding:26px 23px;position:sticky;box-shadow:0 10px 35px #28496b06}.guide-eyebrow{letter-spacing:.8px;text-transform:uppercase;color:#3569af;font-size:10px;font-weight:600}.profile-quick-guide h2{letter-spacing:-.6px;color:#29425e;margin-top:7px;font-size:23px;font-weight:650}.guide-intro{color:#65748a;margin-top:8px;font-size:12px;line-height:1.75}.guide-steps{gap:23px;margin:25px 0 0;padding:0;list-style:none;display:grid}.guide-steps li{grid-template-columns:22px minmax(0,1fr);gap:12px;margin:0;padding:0;display:grid}.guide-step-number{font-variant-numeric:tabular-nums;color:#6b87aa;padding-top:3px;font-size:10px;font-weight:650}.guide-steps li>div>a:first-child{color:#354f6e;justify-content:space-between;align-items:baseline;gap:5px;font-size:13px;font-weight:600;line-height:1.6;display:flex}.guide-steps li>div>a:first-child>span{color:#6b83a0;font-size:12px;transition:transform .16s}.guide-steps li>div>a:hover{color:#2764b1}.guide-steps li>div>a:hover>span{transform:translate(2px,-2px)}.guide-steps p{color:#6c7c90;margin-top:5px;font-size:12px;line-height:1.8}.guide-steps small{color:#65748a;margin-top:4px;font-size:10px;line-height:1.75;display:block}.guide-steps .guide-secondary{color:#5579a0;margin-top:6px;font-size:10px;font-weight:450;line-height:1.6;display:inline-block}.profile-v3 .profile-quick-guide .source-ref{vertical-align:baseline;background:#fff;border:0;min-width:17px;min-height:20px;font-size:10px}.guide-context{color:#65748a;border-top:1px solid #edf1f5;align-items:flex-start;gap:8px;margin-top:23px;padding-top:18px;font-size:10px;line-height:1.85;display:flex}.guide-context svg{color:#90a6be;flex-shrink:0;margin-top:3px}.profile-v2.profile-v3 #molecular,.profile-v2.profile-v3 #pharmacokinetics,.profile-v2.profile-v3 #expectations{border-top:1px solid #e7edf3;padding-top:32px}.profile-v2.profile-v3 #molecular .detail-section-heading{margin-bottom:21px}.profile-v2.profile-v3 #molecular .sequence-heading h3{color:#65748a;font-size:12px;font-weight:500}.profile-v2.profile-v3 #molecular .molecule-stats{max-width:740px}.profile-v2.profile-v3 #molecular .molecule-details{max-width:900px}.profile-v2.profile-v3 #molecular .molecule-stats>div>span{color:#65748a;font-size:11px}.profile-v2.profile-v3 #molecular .molecule-stats strong{color:#526980;font-size:16px}.profile-v2.profile-v3 .section-kicker{color:#6b94a2;letter-spacing:1px;margin-bottom:9px;font-size:9px;font-weight:550;display:block}.profile-v2.profile-v3 .pk-model-select{max-width:700px}.profile-v2.profile-v3 .pk-model-select select{background:#fff;border-color:#dbe5ed;border-radius:8px}.profile-v2.profile-v3 .pk-evidence-note{background:#fff;border:0;border-left:2px solid #d2b878;max-width:770px;padding:4px 0 4px 15px}.profile-v2.profile-v3 .pk-facts strong{font-size:27px}.profile-v2.profile-v3 .pk-chart{max-width:680px}.profile-v2.profile-v3 .pk-duration-summary{border-top:0;margin-top:0;padding-top:0}.profile-v2.profile-v3 .quiet-details{border-color:#edf0f4;margin-top:15px;padding:15px 0}.profile-v2.profile-v3 .quiet-details>summary{color:#7186a1;font-size:12px}.profile-v2.profile-v3 .quiet-details>p,.profile-v2.profile-v3 .quiet-details li{font-size:12px}.profile-v2.profile-v3 [data-profile-section]+[data-profile-section]{border-top:1px solid #e5ebf2;margin-top:48px;padding-top:40px}.profile-v2.profile-v3 .profile-fold{background:#fff;border:0;border-top:1px solid #e8edf3;border-radius:0;margin:0 0 42px;padding:0}.profile-v2.profile-v3 .profile-fold>summary{color:#67809c;padding:19px 0;font-size:14px}.profile-v2.profile-v3 .profile-fold>summary>span{color:#65748a;font-size:11px}.profile-v2.profile-v3 .finding-item{border:0;padding:18px 0}.profile-v2.profile-v3 .finding-item h3,.profile-v2.profile-v3 .finding-item h4{color:#35506d;letter-spacing:-.2px;font-size:17px;line-height:1.6}.profile-v2.profile-v3 .finding-item p{color:#6b7a8d;max-width:880px;margin-top:9px;font-size:14px;line-height:1.9}.profile-v2.profile-v3 .source-corrections{background:#fff;border:0;border-left:2px solid #decb9d;margin-bottom:28px;padding:0 0 0 17px}.profile-v2.profile-v3 .source-corrections p{color:#8b7c65;font-size:12px}.profile-v2.profile-v3 .reference-cautions{background:#fff;border:0;border-top:1px solid #e9edf3;margin-top:20px;padding:24px 0}.profile-v2.profile-v3 .reference-cautions article{border:0;padding:14px 0}.profile-v2.profile-v3 .reference-cautions p{color:#778496;font-size:13px;line-height:1.85}.profile-v2.profile-v3 .interaction-row{border:0;padding:20px 0}.profile-v2.profile-v3 .interaction-row p{color:#65778c;font-size:13px}.profile-v2.profile-v3 .interaction-row-title h3{font-size:16px}.profile-v2.profile-v3 .reference-tools{background:#fff;padding:0 0 16px}.profile-v2.profile-v3 .source-list{border:0}.profile-v2.profile-v3 .reference-entry{border:0;border-bottom:1px solid #e7edf4;padding:20px 0}.profile-v2.profile-v3 .source-card{box-shadow:none;background:#fff;border:0;border-radius:0}.profile-v2.profile-v3 .source-title{font-size:14px;line-height:1.7}.profile-v2.profile-v3 .original-source{font-size:11px}.profile-v2.profile-v3 .expectation-columns article{border:0;padding:15px 0}.profile-v2.profile-v3 .expectation-columns h4{font-size:16px}.profile-v2.profile-v3 .expectation-columns p{color:#6c7d91;font-size:13px}.profile-v2.profile-v3 .reported-expectations{background:#fff;border:0;border-top:1px solid #eceff4;padding:22px 0 0}.profile-v2.profile-v3 .expectation-columns h3{font-size:13px}.profile-v2.profile-v3 .cycle-card{border:0;padding:22px 0}.profile-v2.profile-v3 .cycle-timing h5{color:#7990a6;margin:13px 0 5px;font-size:11px;font-weight:500}.profile-v2.profile-v3 .cycle-timing p{color:#718399;font-size:13px;line-height:1.8}.profile-v2.profile-v3 .preparation-explanation{margin:23px 0}.profile-v2.profile-v3 .preparation-explanation h3{letter-spacing:0;color:#46617e;font-size:15px}.profile-v2.profile-v3 .preparation-explanation p{color:#718095;max-width:900px;margin-top:8px;font-size:13px;line-height:1.85}.profile-v2.profile-v3 .storage-limit{box-shadow:none}@media (width<=1000px){.profile-hero{padding-inline:20px}.hero-inner,.detail-page.profile-v2.profile-v3.wrap{padding-inline:28px}.profile-v2.profile-v3 .profile-overview-layout{grid-template-columns:minmax(0,1fr) 290px;gap:36px}.hero-use-summary{gap:10px 22px}.hero-facts{gap:20px}.hero-facts strong{font-size:18px}.profile-quick-guide{padding:23px 20px}}@media (width<=800px){.profile-v2.profile-v3 .profile-overview-layout{flex-direction:column;gap:36px;display:flex}.profile-quick-guide{order:-1;width:100%;position:static}.guide-steps{grid-template-columns:1fr 1fr;gap:24px 30px}.guide-context{max-width:650px}}@media (width<=600px){.profile-hero{padding:14px 12px 0}.hero-inner{border-radius:15px 15px 0 0;padding:18px 20px 23px}.profile-hero .breadcrumb{margin-bottom:18px;font-size:10px}.hero-heading{align-items:flex-start;gap:14px;position:relative}.profile-hero .profile-labels{margin-bottom:10px;padding-right:77px}.profile-hero h1{letter-spacing:-1.2px;font-size:36px;line-height:1.15}.profile-hero h1.long-profile-title{letter-spacing:-.9px;font-size:29px;line-height:1.2}.hero-tagline{margin-top:9px;font-size:12px;line-height:1.8}.profile-hero .detail-actions{gap:5px;position:absolute;top:-5px;right:0}.hero-icon-action{border-color:#e8edf3;border-radius:7px;width:31px;min-height:31px;padding:5px}.hero-icon-action>span{display:none}.hero-use-summary{gap:11px;margin-top:20px;display:grid}.hero-use-summary>div{display:block}.hero-use-summary>div>span{margin-bottom:2px;font-size:10px;display:block}.hero-use-summary strong{font-size:12px;line-height:1.65}.profile-hero .source-ref{margin-left:4px;font-size:9px}.hero-status{margin-top:13px;font-size:10px;line-height:1.8}.hero-facts{grid-template-columns:1fr 1fr;gap:21px 20px;margin-top:19px;padding-top:20px}.hero-facts a{gap:5px}.hero-facts a>span{font-size:10px}.hero-facts strong{letter-spacing:-.3px;font-size:17px}.hero-facts small{font-size:9px}.detail-page.profile-v2.profile-v3.wrap{padding:0 22px 45px}.profile-v2.profile-v3 .profile-jumpnav{scrollbar-width:none;gap:22px;min-height:57px;margin:0 -22px 31px;padding:0 20px;overflow-x:auto}.profile-v2.profile-v3 .profile-jumpnav::-webkit-scrollbar{display:none}.profile-v2.profile-v3 .profile-jumpnav a{padding:20px 0 17px;font-size:11px}.profile-v2.profile-v3 .profile-jumpnav .profile-sources-link{margin-left:0}.profile-v2.profile-v3 .profile-overview-layout{gap:32px;margin-bottom:38px}.profile-quick-guide{border-radius:13px;padding:23px 20px}.profile-quick-guide h2{font-size:23px}.guide-intro{font-size:11px}.guide-steps{grid-template-columns:1fr;gap:20px;margin-top:23px}.guide-steps li{grid-template-columns:19px 1fr;gap:12px}.guide-context{margin-top:19px;padding-top:16px}.profile-v2.profile-v3 .detail-section h2{letter-spacing:-.65px;font-size:25px}.profile-v2.profile-v3 .detail-section>.detail-section-heading{gap:10px;margin-bottom:20px}.profile-v2.profile-v3 .overview-lead{margin-bottom:23px;font-size:13px;line-height:1.85}.profile-v2.profile-v3 .use-answer p{font-size:13px}.profile-v2.profile-v3 .uses-group>h3>span{margin-left:5px;font-size:9px;display:inline}.profile-v2.profile-v3 .profile-overview-copy>.detail-section{margin-bottom:29px}.profile-v2.profile-v3 .profile-overview-copy>.detail-section:last-child{margin-bottom:0}.profile-v2.profile-v3 #molecular,.profile-v2.profile-v3 #pharmacokinetics,.profile-v2.profile-v3 #expectations{padding-top:28px}.profile-v2.profile-v3 [data-profile-section]>.detail-section,.profile-v2.profile-v3 .preparation-reference>.detail-section{margin-bottom:40px}.profile-v2.profile-v3 .pk-facts strong{font-size:23px}.profile-v2.profile-v3 .pk-facts>div:nth-child(2) strong{font-size:12px}.profile-v2.profile-v3 .finding-item h3,.profile-v2.profile-v3 .finding-item h4{font-size:16px}.profile-v2.profile-v3 .finding-item p{font-size:13px}.profile-v2.profile-v3 .source-ref{min-width:23px;min-height:23px;font-size:10px}.profile-v2.profile-v3 .profile-fold>summary>span{font-size:10px}.profile-v2.profile-v3 [data-profile-section]+[data-profile-section]{margin-top:35px;padding-top:31px}}@media (prefers-reduced-motion:reduce){.profile-page *{scroll-behavior:auto!important;transition:none!important;animation:none!important}}@media print{.profile-hero{background:#fff;padding:0}.hero-inner{box-shadow:none}.profile-quick-guide{box-shadow:none;position:static}.profile-v2.profile-v3 .profile-jumpnav{position:static}.profile-page [data-profile-reveal]{opacity:1!important;transform:none!important}}